RAB11FIP4 - RAB11 family interacting protein 4 Gene

Also Known as FIP4-Rab11; RAB11-FIP4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84440

About RAB11FIP4

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:31,391,675-31,538,211 (from NCBI)

This gene has 11 transcripts (splice variants), 283 orthologues and 1 paralogue. Broad expression in brain (RPKM 25.4), testis (RPKM 6.0) and 17 other tissues.

Summary

The protein encoded by this gene interacts with RAB11 and is thought to be involved in bringing recycling endosome membranes to the cleavage furrow in late cytokinesis. Hypoxic conditions can lead to an upregulation of the encoded protein and enhance the metastatic potential of hepatocellular carcinoma. [provided by RefSeq, Oct 2016]

RAB11FIP4 Products (5)

mRNA Protein Name
NM_001303542.3 NP_001290471.2 rab11 family-interacting protein 4 isoform 2
NM_001346747.2 NP_001333676.1 rab11 family-interacting protein 4 isoform 3
NM_001346748.2 NP_001333677.1 rab11 family-interacting protein 4 isoform 4
NM_001346749.2 NP_001333678.1 rab11 family-interacting protein 4 isoform 5
NM_032932.6 NP_116321.2 rab11 family-interacting protein 4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12470645 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
12470645 GOA
enables small GTPase binding IPI
IPI: Inferred from physical interaction
12470645 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of cytokinesis IMP
IMP: Inferred from mutant phenotype
16148947 GOA
Cellular Component GO Annotation Evidence References Source
located in cleavage furrow IDA
IDA: Inferred from direct assay
15601896 GOA
located in endocytic vesicle IDA
IDA: Inferred from direct assay
20682791 GOA
located in endosome IDA
IDA: Inferred from direct assay
20682791 GOA
located in midbody IDA
IDA: Inferred from direct assay
15601896 GOA
located in recycling endosome membrane IDA
IDA: Inferred from direct assay
12470645 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB11FIP4 Protein Structure

RBD-FIP

RBD-FIP: FIP domain (596 - 636)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 637 a.a.
Protein Preferred Names Protein Names

rab11 family-interacting protein 4

  • RAB11 family interacting protein 4 (class II)

RAB11FIP4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RAB11FIP4 Q86YS3 MAD2L2 Homo sapiens Q9UI95
Validated Y2H
32296183
Cross
RAB11FIP4 Q86YS3 Arf6 Mus musculus P62331
Pull Down
22522702
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Chromosome 17q11.2 Deletion Syndrome

  • Nf1 Microdeletion Syndrome

  • 17q11 Microdeletion Syndrome

  • Neurofibromatosis Type 1 Microdeletion Syndrome

  • Van Asperen Syndrome

  • Del(17)(Q11)

  • Monosomy 17q11

  • Chromosome 17q11.2 Deletion Syndrome, 1.4mb
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11519 RAB11FIP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus RAB11FIP4 VGNC VGNC:64470
Bos taurus RAB11FIP4 VGNC VGNC:33619
Mus musculus RAB11FIP4 MGD MGI:2442920
Macaca mulatta RAB11FIP4 VGNC VGNC:76571
Canis familiaris RAB11FIP4 VGNC VGNC:45251
Rattus norvegicus RAB11FIP4 RGD RGD:1305063
Others RAB11FIP4 NCBI