PLPP5 - phospholipid phosphatase 5 Gene

Also Known as DPPL1; HTPAP; PPAPDC1B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84513

Summary

Enables diacylglycerol diphosphate Phosphatase activity and phosphatidate Phosphatase activity. Involved in phospholipid dephosphorylation. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Ubiquitous expression in prostate (RPKM 24.6), duodenum (RPKM 12.1) and 25 other tissues.

PLPP5 Products (10)

mRNA Protein Name
NM_001102559.2 NP_001096029.1 phospholipid phosphatase 5 isoform 1
NM_001102560.2 NP_001096030.1 phospholipid phosphatase 5 isoform 3
NM_001354452.2 NP_001341381.1 phospholipid phosphatase 5 isoform 4
NM_001354454.2 NP_001341383.1 phospholipid phosphatase 5 isoform 5
NM_001354456.2 NP_001341385.1 phospholipid phosphatase 5 isoform 6
NM_001354457.2 NP_001341386.1 phospholipid phosphatase 5 isoform 7
NM_001354458.2 NP_001341387.1 phospholipid phosphatase 5 isoform 8
NM_001354459.2 NP_001341388.1 phospholipid phosphatase 5 isoform 8
NM_001410920.1 NP_001397849.1 phospholipid phosphatase 5 isoform 9
NM_032483.4 NP_115872.2 phospholipid phosphatase 5 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables diacylglycerol diphosphate phosphatase activity IDA
IDA: Inferred from direct assay
17590538 GOA
enables phosphatidate phosphatase activity IDA
IDA: Inferred from direct assay
17590538 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in phospholipid dephosphorylation IDA
IDA: Inferred from direct assay
17590538 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLPP5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PLPP5 Q8NEB5 q96fb2_human Homo sapiens Q96FB2
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10734 PLPP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10735 PLPP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10736 PLPP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10737 PLPP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20464 Plpp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26973 Plpp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown