USP32 - ubiquitin specific peptidase 32 Gene

Also Known as USP10; NY-REN-60

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84669

About USP32

Cytogenetic location: 17q23.1-q23.2 Genomic coordinates (GRCh38): 17:60,177,327-60,422,416 (from NCBI)

This gene has 15 transcripts (splice variants), 223 orthologues and 71 paralogues. Broad expression in testis (RPKM 36.8), brain (RPKM 14.5) and 23 other tissues.

Summary

Enables thiol-dependent Deubiquitinase. Predicted to be involved in protein deubiquitination. Located in Golgi apparatus and cytosol. [provided by Alliance of Genome Resources, Apr 2022]

USP32 Products (1)

mRNA Protein Name
NM_032582.4 NP_115971.2 ubiquitin carboxyl-terminal hydrolase 32

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
20549504 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24705354 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of TORC1 signaling IMP
IMP: Inferred from mutant phenotype
36476874 GOA
Cellular Component GO Annotation Evidence References Source
is active in Golgi apparatus IDA
IDA: Inferred from direct assay
36476874 GOA
located in Golgi apparatus IDA
IDA: Inferred from direct assay
20549504 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP32 Protein Structure

EF-hand_5

EF-hand_5: EF hand (236 - 253)

EF-hand_5

EF-hand_5: EF hand (272 - 293)

DUSP

DUSP: DUSP domain (393 - 586)

Ubiquitin_3

Ubiquitin_3: Ubiquitin-like domain (641 - 710)

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (734 - 1564)

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  • 1604 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 32

  • deubiquitinating enzyme 32

USP32 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
USP32 Q8NFA0 ZDHHC17 Homo sapiens Q8IUH5
Y2H Array
24705354
Intra
USP32 Q8NFA0 ZDHHC17 Homo sapiens Q8IUH5
Lumier
24705354
Intra
USP32 Q8NFA0 NME4 Homo sapiens O00746
Anti Tag CoIP
33961781
Intra
USP32 Q8NFA0 NME4 Homo sapiens O00746
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

USP32 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811034 USP32 Antibody WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Multiple Benign Circumferential Skin Creases On Limbs

  • Ccsf

  • Circumferential Skin Creases, Kunze Type

  • Congenital Circumferential Skin Folds

  • Kunze-Riehm Syndrome

  • Kunze Riehm Syndrome

  • Michelin Tire Baby Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-178124 Huib32 Inhibitor 98.72% Unkown
HY-RS15543 USP32 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22901 Usp32 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29415 Usp32 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus USP32 RGD RGD:1306657
Bos taurus USP32 VGNC VGNC:36722
Mus musculus USP32 MGD MGI:2144475
Canis familiaris USP32 VGNC VGNC:48188
Felis catus USP32 VGNC VGNC:99569
Others USP32 NCBI