Plcb2 - phospholipase C, beta 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 85240

Summary

Enables G-protein beta/gamma-subunit complex binding activity; phosphatidylinositol Phospholipase C activity; and phospholipid binding activity. Involved in detection of chemical stimulus involved in sensory perception of bitter taste and Phospholipase C-activating G protein-coupled receptor signaling pathway. Located in Golgi apparatus; cytosol; and plasma membrane. Part of G-protein beta/gamma-subunit complex. Orthologous to human PLCB2 (Phospholipase C beta 2). [provided by Alliance of Genome Resources, Apr 2022]

Plcb2 Products (1)

mRNA Protein Name
NM_053478.2 NP_445930.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G-protein beta/gamma-subunit complex binding IDA
IDA: Inferred from direct assay
9931017 RGD
enables phosphatidylinositol phospholipase C activity IMP
IMP: Inferred from mutant phenotype
9860142 RGD
enables phospholipase C activity IMP
IMP: Inferred from mutant phenotype
9860142 RGD
enables phospholipid binding IDA
IDA: Inferred from direct assay
9931017 RGD
Biological Process GO Annotation Evidence References Source
involved in detection of chemical stimulus involved in sensory perception of bitter taste IDA
IDA: Inferred from direct assay
9860142 RGD
involved in detection of chemical stimulus involved in sensory perception of bitter taste IMP
IMP: Inferred from mutant phenotype
9860142 RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
9860142 RGD
Cellular Component GO Annotation Evidence References Source
part of G-protein beta/gamma-subunit complex IDA
IDA: Inferred from direct assay
9931017 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

  • PKC beta II

  • PLC-beta-2

  • phosphoinositide phospholipase C-beta-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10653 PLCB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22731 Plcb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29245 Plcb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plcb2 NCBI NCBI:5330