CPNE3 - copine 3 Gene

Also Known as CPN3; PRO1071

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8895

About CPNE3

Cytogenetic location: 8q21.3 Genomic coordinates (GRCh38): 8:86,514,435-86,561,498 (from NCBI)

This gene has 13 transcripts (splice variants), 208 orthologues and 8 paralogues. Ubiquitous expression in thyroid (RPKM 40.1), esophagus (RPKM 38.1) and 25 other tissues.

Summary

Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a protein which contains two type II C2 domains in the amino-terminus and an A domain-like sequence in the carboxy-terminus. The A domain mediates interactions between integrins and extracellular ligands. [provided by RefSeq, Aug 2008]

CPNE3 Products (1)

mRNA	Protein	Name
NM_003909.5	NP_003900.1	copine-3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables calcium-dependent phospholipid binding	IDA IDA: Inferred from direct assay	9430674	GOA
enables calcium-dependent protein binding	IDA IDA: Inferred from direct assay	20010870	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20010870	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	11041869	GOA
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	20010870	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in ERBB2 signaling pathway	IDA IDA: Inferred from direct assay	20010870	GOA
involved in cellular response to calcium ion	IDA IDA: Inferred from direct assay	20010870	GOA
involved in cellular response to growth factor stimulus	IDA IDA: Inferred from direct assay	20010870	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	20010870	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cell junction	IDA IDA: Inferred from direct assay	20010870	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	20010870	GOA
located in cytosol	IDA IDA: Inferred from direct assay	12949241	GOA
located in focal adhesion	IDA IDA: Inferred from direct assay	20010870	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20010870	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	20010870	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CPNE3 Protein Structure

C2

Copine

0
100
200
300
400
500
537 a.a.

Protein Preferred Names	Protein Names
copine-3	copine III

CPNE3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	CPNE3	O75131	TINF2	Homo sapiens	Q9BSI4	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Bardet-Biedl Syndrome 2	BBS2 Bardet-Biedl Syndrome Bardet-Biedl Syndrome, Type 2 Bbs
Multiple Epiphyseal Dysplasia Due To Collagen 9 Anomaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS03105	CPNE3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21537	Cpne3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28055	Cpne3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CPNE3	MGD	MGI:1917818
Rattus norvegicus	CPNE3	RGD	RGD:1310178
Bos taurus	CPNE3	VGNC	VGNC:27660
Felis catus	CPNE3	VGNC	VGNC:61130
Canis familiaris	CPNE3	VGNC	VGNC:39562
Macaca mulatta	CPNE3	VGNC	VGNC:71465
Others	CPNE3	NCBI