HERC3 - HECT and RLD domain containing E3 ubiquitin protein ligase 3 Gene

Homo sapiens

Gene ID: 8916 | Gene type: protein coding

About HERC3

Cytogenetic location: 4q22.1 Genomic coordinates (GRCh38): 4:88,523,843-88,708,539 (from NCBI)

This gene has 9 transcripts (splice variants), 209 orthologues and 24 paralogues. Ubiquitous expression in prostate (RPKM 6.4), thyroid (RPKM 5.6) and 25 other tissues.

Summary

This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]

HERC3 Products(10)

mRNA	Protein	Name
NM_001271602.2	NP_001258531.1	probable E3 ubiquitin-protein ligase HERC3 isoform 2
NM_001318505.2	NP_001305434.1	probable E3 ubiquitin-protein ligase HERC3 isoform 3
NM_001375477.1	NP_001362406.1	probable E3 ubiquitin-protein ligase HERC3 isoform 4
NM_001375478.1	NP_001362407.1	probable E3 ubiquitin-protein ligase HERC3 isoform 5
NM_001375479.1	NP_001362408.1	probable E3 ubiquitin-protein ligase HERC3 isoform 5
NM_001375480.1	NP_001362409.1	probable E3 ubiquitin-protein ligase HERC3 isoform 6
NM_001375481.1	NP_001362410.1	probable E3 ubiquitin-protein ligase HERC3 isoform 7
NM_001375482.1	NP_001362411.1	probable E3 ubiquitin-protein ligase HERC3 isoform 5
NM_001375483.1	NP_001362412.1	probable E3 ubiquitin-protein ligase HERC3 isoform 5
NM_014606.3	NP_055421.1	probable E3 ubiquitin-protein ligase HERC3 isoform 1

HERC3 Protein Structure

RCC1

HECT

0
200
400
600
800
1050 a.a.

Protein Preferred Names

Protein Names

probable E3 ubiquitin-protein ligase HERC3

HECT domain and RCC1-like domain-containing protein 3

Related Diseases

Diseases

Alias

Atypical Follicular Adenoma

Epidural Abscess

Abscess Epidural

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06128	HERC3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HERC3	MGD	MGI:1921248
Bos taurus	HERC3	VGNC	VGNC:50190
Canis familiaris	HERC3	VGNC	VGNC:49907
Macaca mulatta	HERC3	VGNC	VGNC:73365
Rattus norvegicus	HERC3	RGD	RGD:1307803

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