country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

HERC3 - HECT and RLD domain containing E3 ubiquitin protein ligase 3 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8916

About HERC3

Cytogenetic location: 4q22.1 Genomic coordinates (GRCh38): 4:88,523,843-88,708,539 (from NCBI)

This gene has 9 transcripts (splice variants), 209 orthologues and 24 paralogues. Ubiquitous expression in prostate (RPKM 6.4), thyroid (RPKM 5.6) and 25 other tissues.

Summary

This gene encodes a member the HERC ubiquitin Ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]

HERC3 Products (10)

mRNA	Protein	Name
NM_001271602.2	NP_001258531.1	probable E3 ubiquitin-protein ligase HERC3 isoform 2
NM_001318505.2	NP_001305434.1	probable E3 ubiquitin-protein ligase HERC3 isoform 3
NM_001375477.1	NP_001362406.1	probable E3 ubiquitin-protein ligase HERC3 isoform 4
NM_001375478.1	NP_001362407.1	probable E3 ubiquitin-protein ligase HERC3 isoform 5
NM_001375479.1	NP_001362408.1	probable E3 ubiquitin-protein ligase HERC3 isoform 5
NM_001375480.1	NP_001362409.1	probable E3 ubiquitin-protein ligase HERC3 isoform 6
NM_001375481.1	NP_001362410.1	probable E3 ubiquitin-protein ligase HERC3 isoform 7
NM_001375482.1	NP_001362411.1	probable E3 ubiquitin-protein ligase HERC3 isoform 5
NM_001375483.1	NP_001362412.1	probable E3 ubiquitin-protein ligase HERC3 isoform 5
NM_014606.3	NP_055421.1	probable E3 ubiquitin-protein ligase HERC3 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HERC3 Protein Structure

RCC1

HECT

0
200
400
600
800
1000
1050 a.a.

Protein Preferred Names	Protein Names
probable E3 ubiquitin-protein ligase HERC3	HECT domain and RCC1-like domain-containing protein 3

HERC3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HERC3	Q15034	RPL23A	Homo sapiens	P62750	Anti Bait CoIP	35637966
Intra	HERC3	Q15034	RPL23A	Homo sapiens	P62750	Anti Tag CoIP	35637966
Intra	HERC3	Q15034	RPL23A	Homo sapiens	P62750	Pull Down	35637966
Intra	HERC3	Q15034	RPL23A	Homo sapiens	P62750	IF	35637966

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Atypical Follicular Adenoma
Epidural Abscess	Abscess Epidural

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06128	HERC3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HERC3	MGD	MGI:1921248
Bos taurus	HERC3	VGNC	VGNC:50190
Canis familiaris	HERC3	VGNC	VGNC:49907
Macaca mulatta	HERC3	VGNC	VGNC:73365
Rattus norvegicus	HERC3	RGD	RGD:1307803
Others	HERC3	NCBI