ZNF622 - zinc finger protein 622 Gene

Also Known as ZPR9

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 90441

About ZNF622

Cytogenetic location: 5p15.1 Genomic coordinates (GRCh38): 5:16,451,519-16,465,800 (from NCBI)

This gene has 1 transcript (splice variant) and 215 orthologues. Ubiquitous expression in heart (RPKM 14.7), colon (RPKM 14.5) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to oxidative stress; positive regulation of JNK cascade; and positive regulation of kinase activity. Located in Golgi apparatus; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

ZNF622 Products (1)

mRNA Protein Name
NM_033414.3 NP_219482.1 cytoplasmic 60S subunit biogenesis factor ZNF622

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables preribosome binding IDA
IDA: Inferred from direct assay
32669547 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21771788 GOA
Biological Process GO Annotation Evidence References Source
involved in intrinsic apoptotic signaling pathway in response to oxidative stress IDA
IDA: Inferred from direct assay
21771788 GOA
involved in positive regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
21771788 GOA
involved in positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
21771788 GOA
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
21771788 GOA
involved in positive regulation of kinase activity IDA
IDA: Inferred from direct assay
21771788 GOA
involved in ribosomal large subunit biogenesis IDA
IDA: Inferred from direct assay
33711283 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF622 Protein Structure

zf-C2H2_jaz

zf-C2H2_jaz: Zinc-finger double-stranded RNA-binding (68 - 91)

zf-C2H2_2

zf-C2H2_2: C2H2 type zinc-finger (2 copies) (253 - 352)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 477 a.a.
Protein Preferred Names Protein Names

cytoplasmic 60S subunit biogenesis factor ZNF622

  • zinc finger-like protein 9

ZNF622 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZNF622 Q969S3 BEND7 Homo sapiens Q8N7W2-2
Y2H Array
32296183
Intra
ZNF622 Q969S3 BEND7 Homo sapiens Q8N7W2-2
Y2H Prey Pooling
32296183
Intra
ZNF622 Q969S3 MACROH2A1 Homo sapiens O75367
Y2H Array
32296183
Intra
ZNF622 Q969S3 MACROH2A1 Homo sapiens O75367
Y2H Prey Pooling
32296183
Intra
ZNF622 Q969S3 MAP3K5 Homo sapiens Q99683
Comigration in Gel
21771788
Intra
ZNF622 Q969S3 MAP3K5 Homo sapiens Q99683
In Gel Kinase Assay
21771788
Intra
ZNF622 Q969S3 MAP3K5 Homo sapiens Q99683
Anti Bait CoIP
21771788
Intra
ZNF622 Q969S3 MAP3K5 Homo sapiens Q99683
Pull Down
21771788
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16160 ZNF622 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ZNF622 VGNC VGNC:48777
Rattus norvegicus ZNF622 RGD RGD:1309146
Macaca mulatta ZNF622 VGNC VGNC:110420
Felis catus ZNF622 VGNC VGNC:67338
Bos taurus ZNF622 VGNC VGNC:37315
Mus musculus ZNF622 MGD MGI:1289282
Others ZNF622 NCBI