MAP7 - microtubule associated protein 7 Gene

Also Known as EMAP115; E-MAP-115

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9053

About MAP7

Cytogenetic location: 6q23.3 Genomic coordinates (GRCh38): 6:136,342,734-136,550,422 (from NCBI)

This gene has 9 transcripts (splice variants), 235 orthologues and 3 paralogues. Broad expression in kidney (RPKM 10.5), brain (RPKM 10.5) and 21 other tissues.

Summary

The product of this gene is a microtubule-associated protein that is predominantly expressed in cells of epithelial origin. Microtubule-associated proteins are thought to be involved in microtubule dynamics, which is essential for cell polarization and differentiation. This protein has been shown to be able to stabilize microtubules, and may serve to modulate microtubule functions. Studies of the related mouse protein also suggested an essential role in microtubule function required for spermatogenesis. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

MAP7 Products (36)

mRNA Protein Name
NM_001198608.3 NP_001185537.1 ensconsin isoform 1
NM_001198609.2 NP_001185538.1 ensconsin isoform 2
NM_001198611.3 NP_001185540.1 ensconsin isoform 4
NM_001198614.2 NP_001185543.1 ensconsin isoform 1
NM_001198615.3 NP_001185544.1 ensconsin isoform 5
NM_001198616.3 NP_001185545.1 ensconsin isoform 6
NM_001198617.3 NP_001185546.1 ensconsin isoform 7
NM_001198618.2 NP_001185547.1 ensconsin isoform 8
NM_001198619.2 NP_001185548.1 ensconsin isoform 8
NM_001388328.1 NP_001375257.1 ensconsin isoform 2
NM_001388329.1 NP_001375258.1 ensconsin isoform 2
NM_001388330.1 NP_001375259.1 ensconsin isoform 2
NM_001388331.1 NP_001375260.1 ensconsin isoform 9
NM_001388332.1 NP_001375261.1 ensconsin isoform 1
NM_001388333.1 NP_001375262.1 ensconsin isoform 1
NM_001388334.1 NP_001375263.1 ensconsin isoform 10
NM_001388335.1 NP_001375264.1 ensconsin isoform 11
NM_001388336.1 NP_001375265.1 ensconsin isoform 12
NM_001388337.1 NP_001375266.1 ensconsin isoform 12
NM_001388338.1 NP_001375267.1 ensconsin isoform 12
NM_001388339.1 NP_001375268.1 ensconsin isoform 13
NM_001388340.1 NP_001375269.1 ensconsin isoform 4
NM_001388341.1 NP_001375270.1 ensconsin isoform 4
NM_001388342.1 NP_001375271.1 ensconsin isoform 14
NM_001388343.1 NP_001375272.1 ensconsin isoform 15
NM_001388344.1 NP_001375273.1 ensconsin isoform 16
NM_001388345.1 NP_001375274.1 ensconsin isoform 17
NM_001388346.1 NP_001375275.1 ensconsin isoform 17
NM_001388347.1 NP_001375276.1 ensconsin isoform 18
NM_001388348.1 NP_001375277.1 ensconsin isoform 8
NM_001388349.1 NP_001375278.1 ensconsin isoform 8
NM_001388350.1 NP_001375279.1 ensconsin isoform 20
NM_001388351.1 NP_001375280.1 ensconsin isoform 20
NM_001388352.1 NP_001375281.1 ensconsin isoform 21
NM_001388353.1 NP_001375282.1 ensconsin isoform 22
NM_003980.6 NP_003971.1 ensconsin isoform 3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
27018634 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP7 Protein Structure

MAP7

MAP7: MAP7 (E-MAP-115) family (456 - 625)

  • 0
  • 200
  • 400
  • 600
  • 749 a.a.
Protein Preferred Names Protein Names

ensconsin

  • dJ325F22.2 (microtubule-associated protein 7 (EMAP115, E-MAP-115))

MAP7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
MAP7 Q14244 nleB1 Escherichia coli O157:H7 Q8XBX8
Anti Tag CoIP
27018634
Cross
MAP7 Q14244 nleB1 Escherichia coli O157:H7 Q8XBX8
CoIP
27018634
Intra
MAP7 Q14244 ZNF114 Homo sapiens Q8NC26
Validated Y2H
32296183
Cross
MAP7 Q14244 espL2 Escherichia coli O157:H7 A0A0H3JP21
Anti Tag CoIP
27018634
Intra
MAP7 Q14244 CLIP4 Homo sapiens Q8N3C7
Validated Y2H
32296183
Intra
MAP7 Q14244 CCDC70 Homo sapiens Q6NSX1
Y2H Prey Pooling
32296183
Intra
MAP7 Q14244 CCDC70 Homo sapiens Q6NSX1
Validated Y2H
32296183
Intra
MAP7 Q14244 CCDC70 Homo sapiens Q6NSX1
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spondylometaphyseal Dysplasia, Kozlowski Type

  • Spondylometaphyseal Dysplasia Kozlowski Type

  • Jequier Kozlowski Skeletal Dysplasia

  • Smd Kozlowski Type

  • SMDK

  • Dysmorphism Arthrogryposis Skeletal Maturation Advanced

  • Jequier-Kozlowski Syndrome

  • Skeletal Dysplasia Jequier-Kozlowski Type

  • Smd, Kozlowski Type
Epiphyseal Dysplasia, Multiple, 4

  • EDM4

  • Multiple Epiphyseal Dysplasia 4

  • Multiple Epiphyseal Dysplasia With Clubfoot

  • Multiple Epiphyseal Dysplasia Type 4

  • Multiple Epiphyseal Dysplasia, Autosomal Recessive

  • Multiple Epiphyseal Dysplasia With Bilayered Patellae

  • Med4

  • Polyepiphyseal Dysplasia Type 4

  • Rmed

  • Autosomal Recessive Multiple Epiphyseal Dysplasia

  • Multiple Epiphyseal Dysplasia With Bilateral Patellae

  • Epiphyseal Dysplasia Multiple 4

  • Multiple Epiphyseal Dysplasia With Double-Layered Patella

  • Dysplasia, Epiphyseal, Multiple, Type 4
Barrett'S Adenocarcinoma

  • Barrett Adenocarcinoma

  • Adenocarcinoma Arising In Barrett'S Mucosa
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-155815 MS9715 99.48% Unkown
HY-RS08087 MAP7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08088 MAP7D1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08089 MAP7D2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08090 MAP7D3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MAP7 VGNC VGNC:97499
Rattus norvegicus MAP7 RGD RGD:1308866
Bos taurus MAP7 VGNC VGNC:31210
Macaca mulatta MAP7 VGNC VGNC:97788
Canis familiaris MAP7 VGNC VGNC:42987
Mus musculus MAP7 MGD MGI:1328328
Others MAP7 NCBI