ZNF598 - zinc finger protein 598, E3 ubiquitin ligase Gene

Also Known as HEL2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 90850

About ZNF598

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,997,654-2,009,821 (from NCBI)

This gene has 9 transcripts (splice variants) and 201 orthologues. Ubiquitous expression in testis (RPKM 7.9), spleen (RPKM 7.8) and 25 other tissues.

Summary

Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and Apoptosis. This protein and Grb10-interacting GYF protein 2 have been identified as a components of the mammalian 4EHP (m4EHP) complex. The complex is thought to function as a translation repressor in embryonic development. [provided by RefSeq, Oct 2012]

ZNF598 Products (3)

mRNA Protein Name
NM_001405664.1 NP_001392593.1 E3 ubiquitin-protein ligase ZNF598 isoform 2
NM_001405665.1 NP_001392594.1 E3 ubiquitin-protein ligase ZNF598 isoform 3
NM_178167.5 NP_835461.2 E3 ubiquitin-protein ligase ZNF598 isoform 1
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase ZNF598

ZNF598 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZNF598 Q86UK7 YWHAE Homo sapiens P62258
Crosslink
36931259
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Parkinson Disease, Late-Onset

  • Parkinson Disease

  • Parkinson'S Disease

  • PD

  • PARK

  • Parkinson Disease, Susceptibility To

  • Late Onset Parkinson'S Disease

  • Late Onset Parkinson Disease

  • Paralysis Agitans

  • Primary Parkinsonism

  • Idiopathic Parkinson Disease

  • Parkinson'S

  • Parkinson Disease, Late-Onset, Susceptibility To

  • Parkinson Disease, Age Of Onset, Modifier

  • Lewy Body Parkinson Disease

  • Idiopathic Parkinson'S Disease

  • Pd - [Parkinson Disease]

  • Parkinson Disease Nos

  • Parkinson, Nos

  • Primary Parkinson Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16157 ZNF598 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ZNF598 RGD RGD:1304900
Canis familiaris ZNF598 VGNC VGNC:48771
Macaca mulatta ZNF598 VGNC VGNC:99638
Mus musculus ZNF598 MGD MGI:2670965
Felis catus ZNF598 VGNC VGNC:67332
Bos taurus ZNF598 VGNC VGNC:37309
Others ZNF598 NCBI