SPSB3 - splA/ryanodine receptor domain and SOCS box containing 3 Gene

Also Known as SSB3; C16orf31

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 90864

About SPSB3

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,776,712-1,782,571 (from NCBI)

This gene has 12 transcripts (splice variants), 254 orthologues and 4 paralogues. Ubiquitous expression in skin (RPKM 23.4), spleen (RPKM 22.6) and 25 other tissues.

Summary

Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be part of SCF ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

SPSB3 Products (2)

mRNA Protein Name
NM_001324081.1 NP_001311010.1 SPRY domain-containing SOCS box protein 3
NM_080861.4 NP_543137.2 SPRY domain-containing SOCS box protein 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: Inferred from direct assay
29059170 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cGAS/STING signaling pathway IDA
IDA: Inferred from direct assay
38418882 GOA
involved in negative regulation of epithelial to mesenchymal transition IDA
IDA: Inferred from direct assay
29059170 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
29059170 GOA
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
38418882 GOA
Cellular Component GO Annotation Evidence References Source
part of Cul5-RING ubiquitin ligase complex IDA
IDA: Inferred from direct assay
29059170 GOA
is active in nucleus IDA
IDA: Inferred from direct assay
38418882 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPSB3 Protein Structure

SPRY

SPRY: SPRY domain (147 - 266)

  • 0
  • 100
  • 200
  • 300
  • 355 a.a.
Protein Preferred Names Protein Names

SPRY domain-containing SOCS box protein 3

  • SPRY domain-containing SOCS box protein SSB-3

SPSB3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SPSB3 Q6PJ21 b7z5w0_human Homo sapiens B7Z5W0
Validated Y2H
25416956
Intra
SPSB3 Q6PJ21 ZNF396 Homo sapiens Q96N95-3
Validated Y2H
32296183
Intra
SPSB3 Q6PJ21 ZNF396 Homo sapiens Q96N95-3
Y2H Array
32296183
Intra
SPSB3 Q6PJ21 ZNF396 Homo sapiens Q96N95-3
Y2H Prey Pooling
32296183
Intra
SPSB3 Q6PJ21 ENKD1 Homo sapiens Q9H0I2
Y2H Array
32296183
Intra
SPSB3 Q6PJ21 ENKD1 Homo sapiens Q9H0I2
Y2H Prey Pooling
25416956
Intra
SPSB3 Q6PJ21 ENKD1 Homo sapiens Q9H0I2
Y2H Prey Pooling
32296183
Intra
SPSB3 Q6PJ21 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra
SPSB3 Q6PJ21 NUMBL Homo sapiens Q9Y6R0
Y2H Prey Pooling
32296183
Intra
SPSB3 Q6PJ21 NUMBL Homo sapiens Q9Y6R0
Validated Y2H
32296183
Intra
SPSB3 Q6PJ21 NUMBL Homo sapiens Q9Y6R0
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypochondriasis

  • Hypochondriacal Disorder

  • Hypochondria

  • Hypochondriacal Neurosis

  • Illness Anxiety Disorder

  • Health Anxiety Disorder

  • Hypochondriacal Reaction
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13728 SPSB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21052 Spsb3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27570 Spsb3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SPSB3 MGD MGI:1891471
Rattus norvegicus SPSB3 RGD RGD:1310936
Macaca mulatta SPSB3 VGNC VGNC:78025
Bos taurus SPSB3 VGNC VGNC:35248
Felis catus SPSB3 VGNC VGNC:65656
Canis familiaris SPSB3 VGNC VGNC:46771
Others SPSB3 NCBI