MYOM2 - myomesin 2 Gene

Also Known as TTNAP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9172

About MYOM2

Cytogenetic location: 8p23.3 Genomic coordinates (GRCh38): 8:2,045,046-2,145,456 (from NCBI)

This gene has 15 transcripts (splice variants), 1 gene allele, 279 orthologues and 11 paralogues. Biased expression in heart (RPKM 193.6) and prostate (RPKM 8.7).

Summary

The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD and 165 kD. The predicted MYOM2 protein contains 1,465 Amino acids. Like MYOM1, MYOM2 has a unique N-terminal domain followed by 12 repeat domains with strong homology to either fibronectin type III or immunoglobulin C2 domains. Protein sequence comparisons suggested that the MYOM2 protein and bovine M protein are identical. [provided by RefSeq, Jul 2008]

MYOM2 Products (1)

mRNA	Protein	Name
NM_003970.4	NP_003961.3	myomesin-2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables kinase binding	IPI IPI: Inferred from physical interaction	12972258	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23414517	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in sarcomere organization	IMP IMP: Inferred from mutant phenotype	33033063	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYOM2 Protein Structure

I-set

fn3

Ig_2

I-set

0
300
600
900
1200
1465 a.a.

Protein Preferred Names	Protein Names
myomesin-2	165 kDa connectin-associated protein

MYOM2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MYOM2	P54296	DYSF	Homo sapiens	O75923	PLA	23414517

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Rheumatic Fever	Acute Rheumatic Fever Rhf - Rheumatic Fever Inflammatory Rheumatism Active Rheumatic Fever Nos Acute Active Rheumatic Fever Subacute Active Rheumatic Fever Subacute Rheumatic Fever Active Rheumatic Fever With Unspecified Type Of Heart Involvement Acute Rheumatic Heart Disease Active Rheumatic Heart Disease Acute Organic Rhd - [Rheumatic Heart Disease] Acute Rhd - [Rheumatic Heart Disease]
Blood Protein Disease	Blood Protein Disorders Blood Protein Disorder
Monoclonal Gammopathy Of Uncertain Significance	Monoclonal Gammopathy Of Undetermined Significance Mgus Mgus - [Monoclonal Gammopathy Of Undetermined Significance] Monoclonal Gammopathy Nos Iga Gammopathy Monoclonal Gammoglobulinopathy
Necrotizing Fasciitis	Fasciitis, Necrotizing
Poems Syndrome	Crow-Fukase Syndrome Osteosclerotic Myeloma Polyneuropathy Organomegaly Polyneuropathy, Organomegaly, Endocrinopathy, M Protein, And Skin Changes Syndrome Pep Syndrome Polyneuropathy-Endocrinopathy-Plasma Cell Dyscrasia Syndrome Takatsuki Syndrome
Toxic Shock Syndrome	Septic Shock Toxic Shock Tss Shock, Septic Staphylococcal Toxic Shock Syndrome Tss - [Toxic Shock Syndrome]
Osteosclerotic Myeloma
Non-Secretory Myeloma
Solitary Osseous Plasmacytoma	Isolated Osseous Plasmacytoma Solitary Plasmacytoma Of Bone
Smoldering Myeloma
Rheumatic Heart Disease	Rheumatic Carditis Rheumatic Congestive Heart Failure Congestive Rheumatic Heart Failure Rheumatic Heart Failure RHD Rheumatic Fever Inactive Or Quiescent With Heart Disease Rheumatic Fever Inactive Or Quiescent With Carditis Organ Rheumatic Heart Disease Organic Rheumatic Heart Disease Inactive Rheumatic Heart Disease Rheumatic Heart Rheumatic Fever Inactive Or Quiescent With Pancarditis Rhd - [Rheumatic Heart Disease] Rheumatic Cardiac Hypertrophy Rheumatic Fever Inactive Or Quiescent With Cardiac Hypertrophy Rheumatic Pancarditis Inactive Rhd - [Rheumatic Heart Disease] Rheumatic Nonischaemic Cardiopathy
Glomeruloid Hemangioma
Extramedullary Plasmacytoma	Extraosseous Plasmacytoma Plasmacytoma, Extramedullary
Rheumatic Myocarditis	Acute Rheumatic Myocarditis Active Rheumatic Fever With Myocarditis Acute Rheumatic Carditis Rheumatic Degeneration Of Myocardium Rheumatic Fever With Myocarditis Rheumatoid Myocarditis Acute Rheumatic Heart Disease Acute Rheumatic Fever With Myocarditis Active Or Acute Rheumatic Myocarditis Active Rheumatic Myocarditis Active Rheumatic Progressive Myocarditis Chronic Active Rheumatic Myocarditis Old Active Rheumatic Myocarditis Active Rheumatic Fibroid Myocarditis Active Rheumatic Interstitial Myocarditis Acute Or Subacute Rheumatic Myocardial Insufficiency Acute Rheumatic Toxic Myocarditis Inactive Or Quiescent Rheumatic Fever With Myocarditis Inactive Rheumatic Myocarditis Rheumatic Progressive Myocarditis Rheumatic Fibroid Myocarditis Rheumatic Interstitial Myocarditis Myocardial Degeneration With Rheumatic Fever Myocardial Insufficiency With Rheumatic Fever Rheumatic Cardiomyopathy Dilated Cardiomyopathy Due To Rheumatic Fever Myocarditis Due To Rheumatic Fever Rheumatic Myocardial Insufficiency
Subacute Sclerosing Panencephalitis	SSPE Dawson Encephalitis Immunosuppressive Measles Encephalitis Subacute Sclerosing Leukoencephalitis Panencephalitis, Subacute Sclerosing Subacute Sclerosing Leukoencephalopathy Van Bogaert'S Sclerosing Leukoencephalitis Dawson Disease Subacute Inclusion Body Encephalitis Van Bogaert Disease Van Bogaert Encephalitis Measles Inclusion Body Encephalitis Mibe - [Measles Inclusion Body Encephalitis] Sspe - [Subacute Sclerosing Panencephalitis] Van Bogaert Leukoencephalitis Van Bogaert Sclerosing Leukoencephalitis Dawson Inclusion Body Encephalitis Van Bogaert Sclerosing Leukoencephalopathy Bodechtel Guttman Disease Diffuse Sclerosing Encephalitis
Scarlet Fever	Scarlatina Scarlatina Nos
Spinal Polio
Bulbospinal Polio
Acute Poststreptococcal Glomerulonephritis	Post-Streptococcal Glomerulonephritis Acute Post-Streptococcal Glomerulonephritis
Immunoglobulin Light Chain Amyloidosis	Al Amyloidosis Primary Amyloidosis Primary Systemic Amyloidosis Light Chain Amyloidosis Amyloidosis Al Amyloidosis Primary Systemic Primary Al Amyloidosis Primary Systemic Al Amyloidosis Systemic Al Amyloidsis Systemic Al Amyloidosis Light-Chain Amyloidosis Alys Amyloidosis Familial Amyloid Nephropathy Due To Lysozyme Variant Familial Renal Amyloidosis Due To Lysozyme Variant Hereditary Amyloid Nephropathy Due To Lysozyme Variant Hereditary Renal Amyloidosis Due To Lysozyme Variant Lysozyme Amyloidosis Amyloidosis Primary Immunoglobulin Deposition Disease Immunoglobulinic Amyloidosis Amyloid Al
Indolent Plasma Cell Myeloma	Indolent Myeloma Indolent Multiple Myeloma
Impetigo
Lymphoplasmacytic Lymphoma	Waldenstrom Macroglobulinemia Malignant Lymphoma - Lymphoplasmacytic Waldenström Macroglobulinaemia Waldenström Macroglobulinaemia Without Mention Of Remission Idiopathic Macroglobulinaemia Primary Macroglobulinaemia
Plasma Protein Metabolism Disease
Commensal Bacterial Infectious Disease
Acute Serous Otitis Media	Acute Non-Suppurative Otitis Media - Serous Acute Transudative Otitis Media
Amyloidosis	Amyloid Disease Amyloid Amyloid Degeneration Amyloidosis Nos Amyloid Deposition Amyloid Infiltration Idiopathic Amyloidosis Hyaloid Degeneration Lardaceous Degeneration
Heavy Chain Disease	Hcd
Mature B-Cell Neoplasm	Mature B-Cell Lymphocytic Neoplasm Neoplasm Of Mature B-Cells Mature B-Cell Non-Hodgkin Neoplasm With Leukaemic Behaviour
Pharyngitis	Acute Pharyngitis Chronic Pharyngitis Acute Sore Throat Chronic Sore Throat Persistent Sore Throat Pharyngeal Diseases Chronic Pharyn/Nasopharyngitis Chronic Pharyngitis And Nasopharyngitis Inflamed Throat Pharyngeal Disease Pharyngeal Disorder Pharyngitis - Acute Sore Throat - Chronic Acute Pharyngitis Nos Acute Sore Throat Nos Acute Throat Inflammation Infective Pharyngitis Infection Of Pharynx Acute Infective Pharyngitis Acute Infective Pharyngitis Nos Acute Pharyngeal Inflammation Inflammation Of The Throat Throat Inflammation Throat Infection Putrid Pharyngitis Pharyngeal Inflammation Pharyngitis Nos Chronic Throat Pain Throat Catarrh
Papilledema	Choked Disk Edema Of The Optic Disc
Demyelinating Polyneuropathy	Peripheral Demyelinating Neuropathy Demyelinating Peripheral Neuropathy
Pulmonary Coin Lesion	Coin Lesion Of Lung Solitary Pulmonary Nodule Coin Lesion Lung
Pyoderma
Alpha Chain Disease	Seligmann'S Disease Immunoproliferative Small Intestinal Disease
Plasma Cell Leukemia	Plasma Cell Leukaemia Leukemia, Plasma Cell Plasmacytic Leukaemia Plasmacytic Leukemia Pcl Plasma Cell Leukaemia, Nos Leukemic Plasma Cell Plasma Cell Leukaemia Without Mention Of Remission
Pyomyositis	Tropical Pyomyositis Myositis Tropicans Myositis Purulenta Tropica Pm Suppurative Myositis Purulent Myositis
Bone Marrow Cancer	Malignant Neoplasm Of Bone Marrow Bone Marrow Neoplasm Bone Marrow Tumor Malignant Bone Marrow Tumor Myeloproliferative Disorders Bone Marrow Neoplasms Myeloproliferative Disease Chronic Myeloproliferative Disorder
Mononeuritis Of Upper Limb And Mononeuritis Multiplex
Cellulitis
Erysipelas
Chronic Inflammatory Demyelinating Polyradiculoneuropathy	Chronic Inflammatory Demyelinating Polyneuropathy Cidp Polyradiculoneuropathy Chronic Inflammatory Demyelinating Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Tetralogy Of Fallot	TOF Fallot Tetralogy Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle Tetrad Of Fallot Fallot Tetrad Fallot Disease Fallot Complex Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle Interventricular Septal Defect, In Tetralogy Of Fallot Ventricular Septal Defect With Obstructed Right Ventricular Outflow Tof - [Tetralogy Of Fallot] Pulmonary Atresia With Ventricular Septal Defect [Fallot Type] Pulmonary Atresia, Ventricular Septal Defect And Mapcas Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]
Waldenstroem'S Macroglobulinemia	Waldenstrom Macroglobulinemia Macroglobulinemia Of Waldenstrom Waldenström Macroglobulinemia Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstrom'S Macroglobulinaemia Waldenstrom'S Syndrome Waldenstrom'S Macroglobulinemia Wm Waldenström'S Macroglobulinemia Malignant Lymphoma - Lymphoplasmacytic
Mechanical Ectropion
Mineral Metabolism Disease	Mineral Metabolism Disorder Disorder Of Mineral Metabolism
Retinitis Pigmentosa 46	RP46 Retinitis Pigmentosa, Autosomal Recessive, Idh3b-Related Retinitis Pigmentosa Autosomal Recessive Idh3b-Related Retinitis Pigmentosa, Type 46
Streptococcal Meningitis
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Cardiomyopathy, Familial Hypertrophic, 6	Hypertrophic Cardiomyopathy 6 CMH6 Familial Hypertrophic Cardiomyopathy With Wolff-Parkinson-White Syndrome Cardiomyopathy, Familial Hypertrophic 6 Cardiomyopathy, Hypertrophic 6 Cardiomyopathy, Hypertrophic, Familial, Type 6
Leukocyte Disease	Leukocyte Disorders
Proliferative Glomerulonephritis
Mixed Cerebral Palsy	Cerebral Palsy, Mixed
Multicentric Castleman Disease	Mcd Multicentric Giant Lymph Node Hyperplasia Plasmablastic Multicentric Castleman Disease Pmcd Idiopathic Multicentric Castleman Disease Multi-Centric Castleman'S Disease Idiopathic Multicentric Castleman'S Disease Multicentric Plasma Cell Variant Of Castleman'S Disease Hhv-8-Negative Multicentric Castleman Disease Human Herpesvirus-8-Negative Multicentric Castleman Disease
Castleman Disease	Angiofollicular Ganglionic Hyperplasia Angiofollicular Lymph Hyperplasia Giant Lymph Node Hyperplasia Castleman'S Disease Angiofollicular Lymph Node Hyperplasia Lymphoid Hamartoma Benign Giant Lymphoma Angiolymphoid Hyperplasia
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Septic Arthritis	Infectious Arthritis Arthritis, Infectious Arthritis Septic Arthritis, Bacterial
Conjunctival Deposit
Plasma Cell Neoplasm	Plasma Cell Dyscrasia Paraproteinemias Plasma Cell Tumour Plasmacytic Tumor Multiple Myeloma Plasmacytoma Plasma Cell Tumours Plasma Cells Dyscrasia
Heart Valve Disease	Heart Valve Diseases Valvular Heart Disease Valvular Heart Diseases Heart Valve Prolapse
Polyneuropathy	Polyneuropathies
Myopathy, Lactic Acidosis, And Sideroblastic Anemia 3	MLASA3
Lethal Congenital Contracture Syndrome 4	LCCS4 Contracture Syndrome, Lethal, Congenital, Type 4
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Hypertrophic Cardiomyopathy	Hypertrophic Obstructive Cardiomyopathy Cardiomyopathy, Hypertrophic Cardiomyopathy Hypertrophic Obstructive Cardiomyopathy, Hypertrophic, Familial Idiopathic Myocardial Hypertrophy Idiopathic Hypertrophic Cardiomyopathy Obstructive Idiopathic Hypertrophic Cardiomyopathy Obstructive Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Muscular Subaortic Stenosis Hypertrophic Obstructive Subaortic Stenosis
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08961	MYOM2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MYOM2	VGNC	VGNC:105239
Mus musculus	MYOM2	MGD	MGI:1328358
Macaca mulatta	MYOM2	VGNC	VGNC:75124
Rattus norvegicus	MYOM2	RGD	RGD:631437
Bos taurus	MYOM2	VGNC	VGNC:31838
Felis catus	MYOM2	VGNC	VGNC:68406