NAPRT - nicotinate phosphoribosyltransferase Gene

Also Known as NAPRT1; PP3856

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 93100

About NAPRT

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:143,572,874-143,578,330 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele, 188 orthologues and 1 paralogue. Ubiquitous expression in duodenum (RPKM 19.1), small intestine (RPKM 16.7) and 25 other tissues.

Summary

Nicotinic acid (NA; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT; EC 2.4.2.11) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007).[supplied by OMIM, Mar 2008]

NAPRT Products (4)

mRNA Protein Name
NM_001286829.2 NP_001273758.1 nicotinate phosphoribosyltransferase isoform 2
NM_001363145.1 NP_001350074.1 nicotinate phosphoribosyltransferase isoform 3
NM_001363146.1 NP_001350075.1 nicotinate phosphoribosyltransferase isoform 4
NM_145201.6 NP_660202.3 nicotinate phosphoribosyltransferase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nicotinate phosphoribosyltransferase activity IDA
IDA: Inferred from direct assay
17604275 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in response to oxidative stress IMP
IMP: Inferred from mutant phenotype
17604275 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
17604275 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAPRT Protein Structure

NAPRTase

NAPRTase: Nicotinate phosphoribosyltransferase (NAPRTase) family (164 - 219)

NAPRTase

NAPRTase: Nicotinate phosphoribosyltransferase (NAPRTase) family (284 - 416)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 538 a.a.
Protein Preferred Names Protein Names

nicotinate phosphoribosyltransferase

  • FHA-HIT-interacting protein

NAPRT Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NAPRT Q6XQN6 GRAMD2B Homo sapiens Q96HH9
Y2H Prey Pooling
25416956
Intra
NAPRT Q6XQN6 GRAMD2B Homo sapiens Q96HH9
Validated Y2H
25416956
Intra
NAPRT Q6XQN6 GRAMD2B Homo sapiens Q96HH9
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Pellagra

  • Niacin Deficiency

  • Niacin-Tryptophan Deficiency

  • Pellagroid Syndrome
Facial Dermatosis

  • Facial Dermatoses
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-181880 PROTAC NAMPT Degrader-28 Degrader / Unkown
HY-181881 MV78-OH Ligand / Unkown
HY-181882 MV78-OH-C7-COOH / Unkown
HY-RS09033 NAPRT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-181578 Nampt-IN-17 / Unkown
HY-RS22669 Naprt Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29183 Naprt Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NAPRT VGNC VGNC:31885
Mus musculus NAPRT MGD MGI:2442664
Macaca mulatta NAPRT VGNC VGNC:75057
Canis familiaris NAPRT VGNC VGNC:43623
Rattus norvegicus NAPRT RGD RGD:1302945
Felis catus NAPRT VGNC VGNC:63722
Others NAPRT NCBI