SNCAIP - synuclein alpha interacting protein Gene

Also Known as Sph1; SYPH1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9627

About SNCAIP

Cytogenetic location: 5q23.2 Genomic coordinates (GRCh38): 5:122,311,353-122,464,219 (from NCBI)

This gene has 19 transcripts (splice variants), 191 orthologues and is associated with 1 phenotype. Biased expression in ovary (RPKM 8.3), endometrium (RPKM 6.2) and 11 other tissues.

Summary

This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

SNCAIP Products (8)

mRNA	Protein	Name
NM_001242935.3	NP_001229864.1	synphilin-1 isoform 1A
NM_001308100.2	NP_001295029.1	synphilin-1 isoform 2
NM_001308105.1	NP_001295034.1	synphilin-1 isoform B
NM_001308106.1	NP_001295035.1	synphilin-1 isoform D
NM_001308107.2	NP_001295036.1	synphilin-1 isoform E
NM_001308108.1	NP_001295037.1	synphilin-1 isoform F
NM_001308109.2	NP_001295038.1	synphilin-1 isoform G
NM_005460.4	NP_005451.2	synphilin-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	19762560	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10319874	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	15728840	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell death	IDA IDA: Inferred from direct assay	16595633	GOA
acts upstream of or within dopamine metabolic process	IDA IDA: Inferred from direct assay	14506261	GOA
involved in regulation of inclusion body assembly	IDA IDA: Inferred from direct assay	15603737	GOA
acts upstream of or within regulation of neurotransmitter secretion	IDA IDA: Inferred from direct assay	14506261	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	14506261	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNCAIP Protein Structure

Ank_2

0
200
400
600
800
919 a.a.

Protein Preferred Names	Protein Names
synphilin-1

SNCAIP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SNCAIP	Q9Y6H5	SNCA	Homo sapiens	P37840	Y2H	12044636
Intra	SNCAIP	Q9Y6H5	SNCA	Homo sapiens	P37840	Pull Down	19762560
Intra	SNCAIP	Q9Y6H5	SNCA	Homo sapiens	P37840	Confocal	19762560
Intra	SNCAIP	Q9Y6H5	SNCA	Homo sapiens	P37840	Y2H	10319874
Intra	SNCAIP	Q9Y6H5	SNCA	Homo sapiens	P37840	Confocal	10319874
Intra	SNCAIP	Q9Y6H5	SNCA	Homo sapiens	P37840	FCS	19762560
Intra	SNCAIP	Q9Y6H5	SNCAIP	Homo sapiens	Q9Y6H5	Pull Down	19762560
Intra	SNCAIP	Q9Y6H5	SNCAIP	Homo sapiens	Q9Y6H5	Crosslink	19762560
Intra	SNCAIP	Q9Y6H5	SNCA	Homo sapiens	P37840	NMR	19762560

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Parkinson Disease 3, Autosomal Dominant	PARK3 Parkinson Disease 3 Parkinson Disease 3, Autosomal Dominant Lewy Body Parkinson'S Disease 3 Autosomal Dominant Lewy Body Parkinson Disease 3 Autosomal Dominant Parkinson Disease 3 Parkinson Disease Type 3 Autosomal Dominant Parkinson Disease Parkinson Disease, Autosomal Dominant Parkinson Disease, Familial, Type 1
Dementia	Dementias Presenile Dementia Alzheimer Type Dementia Alzheimer Sclerosis Alzheimer Disease Dementia Alzheimer Dementia Primary Degenerative Alzheimer Type Dementia End Stage Alzheimer'S Dementia Alzheimer'S Type Atypical Dementia Alzheimer Type Presenile Dementia Early Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 2 Dementia In Alzheimer Disease With Early Onset Early Onset Alzheimer Type Dementia, Uncomplicated Primary Degenerative Alzheimer Type Dementia, Early Onset Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated Alzheimer Disease Dementia With Early Onset Presenile Sclerosis Presenile Brain Sclerosis Presenile Alzheimer Brain Sclerosis Late Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 1 Dementia In Alzheimer Disease With Late Onset Primary Degenerative Alzheimer Type Dementia, Late Onset Sdat - [Senile Dementia, Alzheimer Type] Alzheimer Disease Dementia With Late Onset Late Onset Alzheimer Brain Sclerosis Senile Alzheimer Brain Disease Senile Alzheimer Brain Sclerosis Senile Primary Degenerative Alzheimer Type Dementia Senile Dementia Of The Alzheimer Type Arteriosclerotic Dementia Strategic-Infarct Dementia Post Stroke Dementia Vascular Cognitive Impairment Vascular Dementia Dementia Of The Lewy Body Type Dementia With Lewy Bodies Sdlt - [Senile Dementia Of The Lewy Body Type] Senile Dementia Of The Lewy Body Type Alcohol-Related Dementia Alcoholic Dementia Nos Alcohol-Induced Dementia Alcoholic Brain Syndrome Chronic Alcoholic Brain Syndrome Alcohol Dementia Late Onset Alcoholic Psychosis Residual And Late-Onset Alcohol-Induced Psychotic Disorder Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder Late-Onset Psychoactive Substance-Induced Psychotic Disorder Inhalant Dementia Volatile Solvents Dementia Dementia In Paralysis Agitans Pdd - [Parkinson Disease Dementia] Dementia Syndrome Of Parkinson Disease Dementia In Parkinson Disease Parkinson Related Dementia Dementia In Huntington Chorea Hiv - [Human Immunodeficiency Virus] Dementia Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex Aids Related Dementia Dementia Due To Niacin Deficiency
Dementia, Lewy Body	Lewy Body Dementia Lewy Body Disease Diffuse Lewy Body Disease Dementia With Lewy Bodies DLB Autosomal Dominant Diffuse Lewy Body Disease Cortical Lewy Body Disease Dementia, Lewy Body, Susceptibility To Lewy Body Dementia, Susceptibility To Senile Dementia Of The Lewy Body Type Dementia Of The Lewy Body Type Lbd Diffuse Lewy Body Disease With Gaze Palsy Dysphasic Dementia Hereditary Lewy Body Type Senile Dementia Lewy Body Variant Of Alzheimer Disease Lewy Bodies Lewy Body Dlbd - [Diffuse Lewy Body Disease] Clbd - [Cortical Lewy Body Disease]
Juvenile-Onset Parkinson'S Disease	Juvenile-Onset Parkinson Disease
Movement Disease	Movement Disorders Movement Disorder
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13485	SNCAIP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SNCAIP	VGNC	VGNC:46597
Macaca mulatta	SNCAIP	VGNC	VGNC:77669
Felis catus	SNCAIP	VGNC	VGNC:65525
Bos taurus	SNCAIP	VGNC	VGNC:35060
Rattus norvegicus	SNCAIP	RGD	RGD:1309283
Mus musculus	SNCAIP	MGD	MGI:1915097
Others	SNCAIP	NCBI