LAPTM4A - lysosomal protein transmembrane 4 alpha Gene

Homo sapiens

Also known as MBNT; Mtrp; LAPTM4; HUMORF13

Gene ID: 9741 | Gene type: protein coding

About LAPTM4A

Cytogenetic location: 2p24.1 Genomic coordinates (GRCh38): 2:20,032,650-20,051,628 (from NCBI)

This gene has 2 transcripts (splice variants), 211 orthologues and 2 paralogues. Ubiquitous expression in endometrium (RPKM 245.2), testis (RPKM 209.5) and 25 other tissues.

Summary

This gene encodes a protein that has four predicted transmembrane domains. The function of this gene has not yet been determined; however, studies in the mouse homolog suggest a role in the transport of small molecules across endosomal and lysosomal membranes. [provided by RefSeq, Jul 2008]

LAPTM4A Products(1)

mRNA	Protein	Name
NM_014713.5	NP_055528.1	lysosomal-associated transmembrane protein 4A

LAPTM4A Protein Structure

Mtp

0
100
200
233 a.a.

Protein Preferred Names

Protein Names

lysosomal-associated transmembrane protein 4A

golgi 4-transmembrane-spanning transporter MTP

Related Diseases

Diseases

Alias

Myofascial Pain Syndrome

Myofascial Pain Syndromes	Myofascial Pain Dysfunction Syndrome
Fibromyalgia

Patellofemoral Pain Syndrome

Plantar Fasciitis

Fasciitis, Plantar

Facial Neuralgia

Shoulder Impingement Syndrome

Impingement Syndrome Of Shoulder Region

Subacromial Impingement

Frozen Shoulder

Adhesive Capsulitis Of Shoulder	Bursitis
Adhesions-Capsulitis,Shoulder	Pericapsulitis Of Shoulder
Duplay Bursitis	Adhesive Shoulder Peritendinitis
Subscapular Adhesion	Shoulder Adhesion
Adhesive Enthesopathy Of Shoulder Region	Adhesive Peritendinitis
Adhesive Shoulder Tenosynovitis	Duplay Periarthritis
Adhesive Shoulder Tendinitis

Epicondylitis

Tennis Elbow	Lateral Epicondylitis
Golfer'S Elbow	Medial Epicondylitis
Andrel Epicondylitis	Archer'S Elbow
Hockey Elbow	Shooter'S Elbow

Heel Spur

Calcaneal Spur

Bursitis

Bursitis, Not Otherwise Specified

Inflammation Of Bursa

Urethral Syndrome

Urethral Disease	Urethral Diseases
Urethra Disease	Abnormality Of The Urethra
Urethral Disorders

Somatoform Disorder

Physiological Malfunction Arising From Mental Factor	Psychosomatic Disorder
Psychophysiologic Disorders

Spondylosis

Lumbar Spondylosis With Myelopathy	Lumbosacral Spondylosis Without Myelopathy
Spondylogenic Compression Of Lumbar Spinal Cord	Spondylogenic Compression Of Thoracic Spinal Cord
Spondylosis With Myelopathy	Thoracic Or Lumbar Spondylosis With Myelopathy

Radiculopathy

Pinched Nerve	Nerve Root Disorder
Radiculopathy, Site Unspecified	Radicular Neuropathy
Radicular Syndrome	Radicular Pain
Radiculitis	Radiculitis Nos
Spinal Root Pain	Nerve Root Neuritis
Radiculopathy In Spondylosis

De Quervain Disease

Radial Styloid Tenosynovitis	Tenosynovitis, De Quervain'S
De Quervain'S Disease	Tenosynovitis Of Radial Styloid Process
Stenosans Tenosynovitis

Paine Syndrome

Pain Disorder	Pain
Microcephaly With Spastic Diplegia	Pain Syndrome

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07521	LAPTM4A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	LAPTM4A	VGNC	VGNC:42583
Mus musculus	LAPTM4A	MGD	MGI:108017
Rattus norvegicus	LAPTM4A	RGD	RGD:735179
Macaca mulatta	LAPTM4A	VGNC	VGNC:74272
Bos taurus	LAPTM4A	VGNC	VGNC:30787

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