LAPTM4A - lysosomal protein transmembrane 4 alpha Gene

Also Known as MBNT; Mtrp; LAPTM4; HUMORF13

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9741

About LAPTM4A

Cytogenetic location: 2p24.1 Genomic coordinates (GRCh38): 2:20,032,650-20,051,628 (from NCBI)

This gene has 2 transcripts (splice variants), 211 orthologues and 2 paralogues. Ubiquitous expression in endometrium (RPKM 245.2), testis (RPKM 209.5) and 25 other tissues.

Summary

This gene encodes a protein that has four predicted transmembrane domains. The function of this gene has not yet been determined; however, studies in the mouse homolog suggest a role in the transport of small molecules across endosomal and lysosomal membranes. [provided by RefSeq, Jul 2008]

LAPTM4A Products (1)

mRNA Protein Name
NM_014713.5 NP_055528.1 lysosomal-associated transmembrane protein 4A

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21224396 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
10942595 GOA
located in late endosome membrane IDA
IDA: Inferred from direct assay
22096579 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
22096579 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LAPTM4A Protein Structure

Mtp

Mtp: Golgi 4-transmembrane spanning transporter (37 - 233)

  • 0
  • 100
  • 200
  • 233 a.a.
Protein Preferred Names Protein Names

lysosomal-associated transmembrane protein 4A

  • golgi 4-transmembrane-spanning transporter MTP

LAPTM4A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LAPTM4A Q15012 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
Intra
LAPTM4A Q15012 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
Intra
LAPTM4A Q15012 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
Intra
LAPTM4A Q15012 TMED8 Homo sapiens Q6PL24
Y2H Prey Pooling
32296183
Intra
LAPTM4A Q15012 TMED8 Homo sapiens Q6PL24
Validated Y2H
32296183
Intra
LAPTM4A Q15012 TMED8 Homo sapiens Q6PL24
Y2H Array
32296183
Intra
LAPTM4A Q15012 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra
LAPTM4A Q15012 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra
LAPTM4A Q15012 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
LAPTM4A Q15012 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
LAPTM4A Q15012 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
LAPTM4A Q15012 EEF1D Homo sapiens P29692-2
Validated Y2H
32814053
Intra
LAPTM4A Q15012 EEF1D Homo sapiens P29692-2
Y2H Array
32814053
Intra
LAPTM4A Q15012 EEF1D Homo sapiens P29692-2
Y2H Pooling
32814053
Intra
LAPTM4A Q15012 UQCRB Homo sapiens P14927
Y2H Array
32814053
Intra
LAPTM4A Q15012 UQCRB Homo sapiens P14927
Y2H Pooling
32814053
Intra
LAPTM4A Q15012 UQCRB Homo sapiens P14927
Validated Y2H
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Myofascial Pain Syndrome

  • Myofascial Pain Syndromes

  • Myofascial Pain Dysfunction Syndrome

  • Fibromyalgia
Patellofemoral Pain Syndrome
Plantar Fasciitis

  • Fasciitis, Plantar
Facial Neuralgia
Shoulder Impingement Syndrome

  • Impingement Syndrome Of Shoulder Region

  • Subacromial Impingement
Frozen Shoulder

  • Adhesive Capsulitis Of Shoulder

  • Bursitis

  • Adhesions-Capsulitis,Shoulder

  • Pericapsulitis Of Shoulder

  • Duplay Bursitis

  • Adhesive Shoulder Peritendinitis

  • Subscapular Adhesion

  • Shoulder Adhesion

  • Adhesive Enthesopathy Of Shoulder Region

  • Adhesive Peritendinitis

  • Adhesive Shoulder Tenosynovitis

  • Duplay Periarthritis

  • Adhesive Shoulder Tendinitis
Epicondylitis

  • Tennis Elbow

  • Lateral Epicondylitis

  • Golfer'S Elbow

  • Medial Epicondylitis

  • Andrel Epicondylitis

  • Archer'S Elbow

  • Hockey Elbow

  • Shooter'S Elbow
Heel Spur

  • Calcaneal Spur
Bursitis

  • Bursitis, Not Otherwise Specified

  • Inflammation Of Bursa
Urethral Syndrome

  • Urethral Disease

  • Urethral Diseases

  • Urethra Disease

  • Abnormality Of The Urethra

  • Urethral Disorders
Somatoform Disorder

  • Physiological Malfunction Arising From Mental Factor

  • Psychosomatic Disorder

  • Psychophysiologic Disorders
Spondylosis

  • Lumbar Spondylosis With Myelopathy

  • Lumbosacral Spondylosis Without Myelopathy

  • Spondylogenic Compression Of Lumbar Spinal Cord

  • Spondylogenic Compression Of Thoracic Spinal Cord

  • Spondylosis With Myelopathy

  • Thoracic Or Lumbar Spondylosis With Myelopathy
Radiculopathy

  • Pinched Nerve

  • Nerve Root Disorder

  • Radiculopathy, Site Unspecified

  • Radicular Neuropathy

  • Radicular Syndrome

  • Radicular Pain

  • Radiculitis

  • Radiculitis Nos

  • Spinal Root Pain

  • Nerve Root Neuritis

  • Radiculopathy In Spondylosis
De Quervain Disease

  • Radial Styloid Tenosynovitis

  • Tenosynovitis, De Quervain'S

  • De Quervain'S Disease

  • Tenosynovitis Of Radial Styloid Process

  • Stenosans Tenosynovitis
Paine Syndrome

  • Pain Disorder

  • Pain

  • Microcephaly With Spastic Diplegia

  • Pain Syndrome
Migraine With Or Without Aura 1

  • Migraine

  • Migraine With Or Without Aura, Susceptibility To, 1

  • Migraine Disorder

  • Migraine Variant

  • Migraines

  • Migraine Disorders

  • Mgr1

  • Mgau

  • Ma

  • Migraine With Or Without Aura

  • Classic Migraine

  • Common Migraine

  • Disorder, Migraine

  • Headache Migraine

  • Headache Migrainous

  • Migraine Headache

  • Migraine Syndrome

  • Headache Including Migraine

  • Migraine, Susceptibility To
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07521 LAPTM4A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris LAPTM4A VGNC VGNC:42583
Mus musculus LAPTM4A MGD MGI:108017
Rattus norvegicus LAPTM4A RGD RGD:735179
Macaca mulatta LAPTM4A VGNC VGNC:74272
Bos taurus LAPTM4A VGNC VGNC:30787
Others LAPTM4A NCBI