SPCS2 - signal peptidase complex subunit 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9789

About SPCS2

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:74,949,266-74,979,033 (from NCBI)

This gene has 8 transcripts (splice variants) and 215 orthologues. Ubiquitous expression in thyroid (RPKM 48.0), prostate (RPKM 34.0) and 25 other tissues.

Summary

Predicted to enable peptidase activity. Predicted to be involved in protein targeting to ER and signal peptide processing. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of signal peptidase complex. [provided by Alliance of Genome Resources, Apr 2022]

SPCS2 Products (1)

mRNA Protein Name
NM_014752.3 NP_055567.2 signal peptidase complex subunit 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
34232536 GOA
Biological Process GO Annotation Evidence References Source
involved in signal peptide processing IDA
IDA: Inferred from direct assay
34388369 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
34388369 GOA
part of signal peptidase complex IPI
IPI: Inferred from physical interaction
34388369 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPCS2 Protein Structure

SPC25

SPC25: Microsomal signal peptidase 25 kDa subunit (SPC25) (55 - 218)

  • 0
  • 100
  • 200
  • 226 a.a.
Protein Preferred Names Protein Names

signal peptidase complex subunit 2

  • SPase 25 kDa subunit

SPCS2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
SPCS2 Q15005 S SARS-CoV-2 P0DTC2
Pull Down
34232536
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Epiphyseal Dysplasia, Multiple, 3

  • EDM3

  • Multiple Epiphyseal Dysplasia 3

  • Epiphyseal Dysplasia, Multiple, 3, With Or Without Myopathy

  • Multiple Epiphyseal Dysplasia 3 With Or Without Myopathy

  • Epiphyseal Dysplasia Multiple 3

  • Dysplasia, Epiphyseal, Multiple, Type 3
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13650 SPCS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22823 Spcs2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29338 Spcs2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SPCS2 MGD MGI:1913874
Felis catus SPCS2 VGNC VGNC:65627
Bos taurus SPCS2 VGNC VGNC:35197
Rattus norvegicus SPCS2 RGD RGD:1311253
Canis familiaris SPCS2 VGNC VGNC:46725
Others SPCS2 NCBI