SPCS2 - signal peptidase complex subunit 2 Gene

Homo sapiens

Gene ID: 9789 | Gene type: protein coding

About SPCS2

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:74,949,266-74,979,033 (from NCBI)

This gene has 8 transcripts (splice variants) and 215 orthologues. Ubiquitous expression in thyroid (RPKM 48.0), prostate (RPKM 34.0) and 25 other tissues.

Summary

Predicted to enable peptidase activity. Predicted to be involved in protein targeting to ER and signal peptide processing. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of signal peptidase complex. [provided by Alliance of Genome Resources, Apr 2022]

SPCS2 Products(1)

mRNA	Protein	Name
NM_014752.3	NP_055567.2	signal peptidase complex subunit 2

SPCS2 Protein Structure

SPC25

0
100
200
226 a.a.

Protein Preferred Names

Protein Names

signal peptidase complex subunit 2

SPase 25 kDa subunit

Related Diseases

Diseases

Alias

Epiphyseal Dysplasia, Multiple, 3

EDM3	Multiple Epiphyseal Dysplasia 3
Epiphyseal Dysplasia, Multiple, 3, With Or Without Myopathy	Multiple Epiphyseal Dysplasia 3 With Or Without Myopathy
Epiphyseal Dysplasia Multiple 3	Dysplasia, Epiphyseal, Multiple, Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13650	SPCS2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SPCS2	MGD	MGI:1913874
Felis catus	SPCS2	VGNC	VGNC:65627
Bos taurus	SPCS2	VGNC	VGNC:35197
Rattus norvegicus	SPCS2	RGD	RGD:1311253
Canis familiaris	SPCS2	VGNC	VGNC:46725

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