RGP1 - RGP1 homolog, RAB6A GEF complex partner 1 Gene

Also Known as KIAA0258

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9827

About RGP1

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:35,749,287-35,790,428 (from NCBI)

This gene has 2 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in thyroid (RPKM 11.4), kidney (RPKM 9.6) and 25 other tissues.

Summary

Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in negative regulation of cellular protein catabolic process; positive regulation of GTPase activity; and retrograde transport, endosome to Golgi. Located in cytosol and plasma membrane. Part of Ric1-Rgp1 guanyl-nucleotide exchange factor complex. [provided by Alliance of Genome Resources, Apr 2022]

RGP1 Products (1)

mRNA Protein Name
NM_001080496.3 NP_001073965.2 RAB6A-GEF complex partner protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
23091056 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22458338 GOA
enables small GTPase binding IDA
IDA: Inferred from direct assay
23091056 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of protein catabolic process IMP
IMP: Inferred from mutant phenotype
23091056 GOA
involved in positive regulation of GTPase activity IDA
IDA: Inferred from direct assay
23091056 GOA
involved in retrograde transport, endosome to Golgi IMP
IMP: Inferred from mutant phenotype
23091056 GOA
Cellular Component GO Annotation Evidence References Source
part of Ric1-Rgp1 guanyl-nucleotide exchange factor complex IDA
IDA: Inferred from direct assay
23091056 GOA
located in cytosol IDA
IDA: Inferred from direct assay
23091056 GOA
located in membrane IDA
IDA: Inferred from direct assay
23091056 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
23091056 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RGP1 Protein Structure

Rgp1

Rgp1: Rgp1 (86 - 159)

Rgp1

Rgp1: Rgp1 (211 - 331)

  • 0
  • 100
  • 200
  • 300
  • 391 a.a.
Protein Preferred Names Protein Names

RAB6A-GEF complex partner protein 2

  • RGP1 retrograde golgi transport homolog

RGP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RGP1 Q92546 RFPL3 Homo sapiens O75679
Y2H Array
32296183
Intra
RGP1 Q92546 RFPL3 Homo sapiens O75679
Y2H Prey Pooling
32296183
Cross
RGP1 Q92546 tax Human T-cell leukemia virus 1 P14079
Y2H Array
22458338
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11897 RGP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11898 RGPD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21421 Rgp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24389 Reg1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27939 Rgp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RGP1 RGD RGD:1311757
Bos taurus RGP1 VGNC VGNC:33908
Felis catus RGP1 VGNC VGNC:64593
Canis familiaris RGP1 VGNC VGNC:45517
Mus musculus RGP1 MGD MGI:1915956
Others RGP1 NCBI