2. Cell Cycle/DNA Damage
  3. CDK
  4. GFB-12811

GFB-12811 is a high selective CDK5 inhibitor with an IC50 of 2.3 nM.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

GFB-12811

GFB-12811 構造式

CAS 番号 : 2775311-17-4

容量 価格（税別） 在庫状況 数量
5 mg $980 在庫あり
10 mg $1372 在庫あり
25 mg $2200 在庫あり
50 mg $3000 在庫あり
100 mg $4050 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

GFB-12811 関連抗体

Top Publications Citing Use of Products

CDK アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

GFB-12811 is a high selective CDK5 inhibitor with an IC50 of 2.3 nM[1].

IC50 & Target[1]

Cdk5/p25

2.3 nM (IC50)

CDK2/CycA

211 nM (IC50)

CDK7/Cyclin H/MAT1

718 nM (IC50)

CDK9/CycT1

894 nM (IC50)

CDK6

3197 nM (IC50)

体外実験

GFB-12811 exhibits a good metabolic stability and a low clearance in mouse hepatocytes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GFB-12811 関連抗体
体内実験

GFB-12811 exhibits oral bioavailability of 25% (3 mg/kg) and 41% (10 mg/kg), which possibly due to the effect of efflux via the Pgp pathway. GFB-12811 has a long half-life of 7.6 h, and a good volume of distribution with Vss=7.3 L/kg (1 mg/kg, iv) in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

449.44

分子式

C22H23F4N5O
CAS 番号
Appearance

Solid

Color

Light yellow to yellow

SMILES

CN1CCC(CC1)[C@@](O)(C2=CC=C3C=NC(NC4=CC(C(F)(F)F)=NC=C4F)=CC3=N2)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 50 mg/mL (111.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2250 mL 11.1250 mL 22.2499 mL
5 mM 0.4450 mL 2.2250 mL 4.4500 mL
10 mM 0.2225 mL 1.1125 mL 2.2250 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 98.04%

COA (245 KB) HNMR (293 KB) LCMS (96 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2250 mL 11.1250 mL 22.2499 mL 55.6248 mL
5 mM 0.4450 mL 2.2250 mL 4.4500 mL 11.1250 mL
10 mM 0.2225 mL 1.1125 mL 2.2250 mL 5.5625 mL
15 mM 0.1483 mL 0.7417 mL 1.4833 mL 3.7083 mL
20 mM 0.1112 mL 0.5562 mL 1.1125 mL 2.7812 mL
25 mM 0.0890 mL 0.4450 mL 0.8900 mL 2.2250 mL
30 mM 0.0742 mL 0.3708 mL 0.7417 mL 1.8542 mL
40 mM 0.0556 mL 0.2781 mL 0.5562 mL 1.3906 mL
50 mM 0.0445 mL 0.2225 mL 0.4450 mL 1.1125 mL
60 mM 0.0371 mL 0.1854 mL 0.3708 mL 0.9271 mL
80 mM 0.0278 mL 0.1391 mL 0.2781 mL 0.6953 mL
100 mM 0.0222 mL 0.1112 mL 0.2225 mL 0.5562 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

GFB-12811 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GFB-128112775311-17-4GFB12811GFB 12811CDKCyclin dependent kinaseselectiveoralADPKDautosomal dominant polycystic kidney diseaseCDK5Inhibitorinhibitorinhibit

最近チェックした製品:

オンラインお問い合わせ

Your information is safe with us. * Required Fields.

製品名

  

カスタマ需要量 *

お名前 *

 

タイトル

メールアドレス *

 

電話番号 *

デパートメント

 

組纖名 *

市区町村

都道府県

国或いは地域 *

      

必ず会社名を記載ください。個人への返信は行いません。

備考

バルクお問い合わせ

Inquiry Information

製品名:
GFB-12811
製品番号:
HY-144117
数量:
MCE 日本正規代理店:

カスタマーレビュー

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

製品名

  

Lot #

お名前 *

 

メールアドレス *

電話番号 *

 

部門 *

組纖名 *

 

国或いは地域 *

備考

Request for HNMR Report

We have received your request and will respond to you as soon as possible.