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Cat. No.: HY-119968

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Granaticin

(Synonyms: Granaticin A; Litmomycin)

Granaticin A inhibits the initial stage of RNA biosynthesis, has anti-Gram-positive bacteria, Mycobacterium (weak) and Vaginal trichomonas activity, but also can inhibit tumor cells.

For research use only. We do not sell to patients.

CAS No.: 19879-06-2
Formula: C₂₂H₂₀O₁₀
Molecular Weight:444.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Granaticin Chemical Structure

CAS No.: 19879-06-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Granaticin A inhibits the initial stage of RNA biosynthesis, has anti-Gram-positive bacteria, Mycobacterium (weak) and Vaginal trichomonas activity, but also can inhibit tumor cells^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	1.3 μM Compound: Granaticin A	Cytotoxicity against human A549 cells by MTT assay Cytotoxicity against human A549 cells by MTT assay	[PMID: 25153802]
HCT-116	IC₅₀	11 μM Compound: Granaticin A	Cytotoxicity against human HCT116 cells by MTT assay Cytotoxicity against human HCT116 cells by MTT assay	[PMID: 25153802]
HeLa	IC₅₀	0.7 μM Compound: Granaticin A	Cytotoxicity against human HeLa cells by MTT assay Cytotoxicity against human HeLa cells by MTT assay	[PMID: 25153802]
HepG2	IC₅₀	6.6 μM Compound: Granaticin A	Cytotoxicity against human HepG2 cells by MTT assay Cytotoxicity against human HepG2 cells by MTT assay	[PMID: 25153802]

Chemical Information

CAS No. 19879-06-2
Molecular Weight 444.39
Formula C₂₂H₂₀O₁₀
SMILES

O[C@@]12C3=C(O)C(C(C4=C([C@@]5([H])[C@@](CC(O5)=O)([H])O[C@H]4C)C6=O)=O)=C6C(O)=C3[C@@](O[C@@H]2C)([H])C[C@H]1O
Synonyms

Granaticin A; Litmomycin
Structure Classification
- Antibiotics
- Other Antibiotics
Initial Source
- Microorganisms
Streptomyces sp. 166
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Qianqian Lv, et al. Sekgranaticin, a SEK34b-Granaticin Hybrid Polyketide from Streptomyces sp. 166. J Org Chem. 2019 Jul 19;84(14):9087-9092. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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