2. Metabolic Enzyme/Protease
  3. FXR
  4. GSK8062

GSK8062 is a farnesoid X receptor (FXR) agonist with activity that improves compound development parameters. Analog 1c of GSK8062 showed a reduction in weight gain and serum glucose levels.

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GSK8062

GSK8062 Chemical Structure

CAS No. : 943549-47-1

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GSK8062 Related Antibodies

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Description

GSK8062 is a farnesoid X receptor (FXR) agonist with activity that improves compound development parameters. Analog 1c of GSK8062 showed a reduction in weight gain and serum glucose levels[1].

Cellular Effect
Cell Line Type Value Description References
CV-1 EC50
68 nM
Compound: 1b, GSK8062
Agonist activity at human FXR LBD transfected in african green monkey CV1 cells after overnight incubation by luciferase reporter gene assay
Agonist activity at human FXR LBD transfected in african green monkey CV1 cells after overnight incubation by luciferase reporter gene assay
[PMID: 21890356]
CV-1 EC50
68 nM
Compound: 1b, GSK-8062
Agonist activity at FXR expressed in african green monkey CV1 cells by luciferase reporter transient transfection assay
Agonist activity at FXR expressed in african green monkey CV1 cells by luciferase reporter transient transfection assay
[PMID: 18621523]
CV-1 EC50
68 nM
Compound: 1b, GSK-8062
Agonist activity at human FXR LBD iexpressed in monkey CV-1 cells assessed as transactivation of luciferase reporter gene expression
Agonist activity at human FXR LBD iexpressed in monkey CV-1 cells assessed as transactivation of luciferase reporter gene expression
[PMID: 21256005]
Molecular Weight

532.41

Formula

C30H23Cl2NO4
CAS No.
SMILES

O=C(C1=C2C=CC(C3=CC=C(OCC4=C(C(C)C)ON=C4C5=C(Cl)C=CC=C5Cl)C=C3)=CC2=CC=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GSK8062 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK8062943549-47-1GSK 8062GSK-8062FXRNR1H4Inhibitorinhibitorinhibit

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