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Cat. No.: HY-111049

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GSK8062

GSK8062 is a farnesoid X receptor (FXR) agonist with activity that improves compound development parameters. Analog 1c of GSK8062 showed a reduction in weight gain and serum glucose levels.

For research use only. We do not sell to patients.

CAS No.: 943549-47-1
Formula: C₃₀H₂₃Cl₂NO₄
Molecular Weight:532.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

GSK8062 Chemical Structure

CAS No.: 943549-47-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

GSK8062 is a farnesoid X receptor (FXR) agonist with activity that improves compound development parameters. Analog 1c of GSK8062 showed a reduction in weight gain and serum glucose levels^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CV-1	EC₅₀	68 nM Compound: 1b, GSK8062	Agonist activity at human FXR LBD transfected in african green monkey CV1 cells after overnight incubation by luciferase reporter gene assay Agonist activity at human FXR LBD transfected in african green monkey CV1 cells after overnight incubation by luciferase reporter gene assay	[PMID: 21890356]
CV-1	EC₅₀	68 nM Compound: 1b, GSK-8062	Agonist activity at FXR expressed in african green monkey CV1 cells by luciferase reporter transient transfection assay Agonist activity at FXR expressed in african green monkey CV1 cells by luciferase reporter transient transfection assay	[PMID: 18621523]
CV-1	EC₅₀	68 nM Compound: 1b, GSK-8062	Agonist activity at human FXR LBD iexpressed in monkey CV-1 cells assessed as transactivation of luciferase reporter gene expression Agonist activity at human FXR LBD iexpressed in monkey CV-1 cells assessed as transactivation of luciferase reporter gene expression	[PMID: 21256005]

Chemical Information

CAS No. 943549-47-1
Molecular Weight 532.41
Formula C₃₀H₂₃Cl₂NO₄
SMILES

O=C(C1=C2C=CC(C3=CC=C(OCC4=C(C(C)C)ON=C4C5=C(Cl)C=CC=C5Cl)C=C3)=CC2=CC=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Conformationally constrained farnesoid X receptor (FXR) agonists: heteroaryl replacements of the naphthalene [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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