GW 590735
Based on 2 publication(s) in Google Scholar
GW 590735 is a potent and selective PPARα agonist. GW 590735 showsEC50=4 nM on PPARα and at least 500-fold selectivity versus PPARδ and PPARγ. GW 590735 can be used for the research of dyslipidemia.
For research use only. We do not sell to patients.
- Purity: 99.44%
- CAS No.: 343321-96-0
- Formula: C23H21F3N2O4S
- Molecular Weight:478.48
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) GW 590735
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CV-1 | EC50 |
>10 μM
Compound: 25a, GW-590735
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Agonist potency at PPARgamma in CV1 cells by cell based transient transfection assay
Agonist potency at PPARgamma in CV1 cells by cell based transient transfection assay
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[PMID: 17243659] |
| CV-1 | EC50 |
>10 μM
Compound: GW-590735
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Transactivation of Gal4-fused human PPARgamma DNA binding domain expressed in african green monkey CV1 cells by luciferase reporter gene assay
Transactivation of Gal4-fused human PPARgamma DNA binding domain expressed in african green monkey CV1 cells by luciferase reporter gene assay
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[PMID: 21112784] |
| CV-1 | EC50 |
>10 μM
Compound: GW-590735
|
Agonist activity at human PPARgamma-LBD expressed in CV1 cells co-transfected with Gal4 after 40 hrs by luciferase based transactivation assay
Agonist activity at human PPARgamma-LBD expressed in CV1 cells co-transfected with Gal4 after 40 hrs by luciferase based transactivation assay
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[PMID: 21515063] |
| CV-1 | EC50 |
0.004 μM
Compound: 25a, GW-590735
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Agonist potency at PPARalpha in CV1 cells by cell based transient transfection assay
Agonist potency at PPARalpha in CV1 cells by cell based transient transfection assay
|
[PMID: 17243659] |
| CV-1 | EC50 |
0.01 μM
Compound: GW-590735
|
Transactivation of Gal4-fused human PPARalpha DNA binding domain expressed in african green monkey CV1 cells by luciferase reporter gene assay
Transactivation of Gal4-fused human PPARalpha DNA binding domain expressed in african green monkey CV1 cells by luciferase reporter gene assay
|
[PMID: 21112784] |
| CV-1 | EC50 |
0.01 μM
Compound: GW-590735
|
Agonist activity at human PPARalpha-LBD expressed in CV1 cells co-transfected with Gal4 after 40 hrs by luciferase based transactivation assay
Agonist activity at human PPARalpha-LBD expressed in CV1 cells co-transfected with Gal4 after 40 hrs by luciferase based transactivation assay
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[PMID: 21515063] |
| CV-1 | EC50 |
2.6 μM
Compound: GW-590735
|
Transactivation of Gal4-fused human PPARdelta DNA binding domain expressed in african green monkey CV1 cells by luciferase reporter gene assay
Transactivation of Gal4-fused human PPARdelta DNA binding domain expressed in african green monkey CV1 cells by luciferase reporter gene assay
|
[PMID: 21112784] |
| CV-1 | EC50 |
2.6 μM
Compound: GW-590735
|
Agonist activity at human PPARdelta-LBD expressed in CV1 cells co-transfected with Gal4 after 40 hrs by luciferase based transactivation assay
Agonist activity at human PPARdelta-LBD expressed in CV1 cells co-transfected with Gal4 after 40 hrs by luciferase based transactivation assay
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[PMID: 21515063] |
| CV-1 | EC50 |
2.83 μM
Compound: 25a, GW-590735
|
Agonist potency at PPARdelta in CV1 cells by cell based transient transfection assay
Agonist potency at PPARdelta in CV1 cells by cell based transient transfection assay
|
[PMID: 17243659] |
GW 590735 (intravenous administration; 2.7 mg/kg; rat) treatment shows Cl, Vd, T1/2, and F% are 5 mL/min/kg, 1 L/kg, 2.4 hours and 47%, respectively[1].
GW 590735 (intravenous administration; 2 mg/kg; dog) treatment shows Cl, Vd, T1/2, and F% are 13 mL/min/kg, 2.8 L/kg, 2.6 hours and 85%, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 343321-96-0
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Appearance Solid
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Molecular Weight 478.48
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Formula C23H21F3N2O4S
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Color White to off-white
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SMILES
OC(C(C)(C)OC(C=C1)=CC=C1CNC(C2=C(C)N=C(C3=CC=C(C(F)(F)F)C=C3)S2)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Exp Mol Med
Cannabidiol triggers fatty acids β-oxidation mediated by Stat2 to facilitate intestinal stem cells regeneration post radiation. [Abstract]2026 May;58(5):1642-1656. PMID: 42120478 -
Solvent & Solubility
DMSO : 250 mg/mL (522.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0900 mL | 10.4498 mL | 20.8995 mL | 52.2488 mL |
| 5 mM | 0.4180 mL | 2.0900 mL | 4.1799 mL | 10.4498 mL | |
| 10 mM | 0.2090 mL | 1.0450 mL | 2.0900 mL | 5.2249 mL | |
| 15 mM | 0.1393 mL | 0.6967 mL | 1.3933 mL | 3.4833 mL | |
| 20 mM | 0.1045 mL | 0.5225 mL | 1.0450 mL | 2.6124 mL | |
| 25 mM | 0.0836 mL | 0.4180 mL | 0.8360 mL | 2.0900 mL | |
| 30 mM | 0.0697 mL | 0.3483 mL | 0.6967 mL | 1.7416 mL | |
| 40 mM | 0.0522 mL | 0.2612 mL | 0.5225 mL | 1.3062 mL | |
| 50 mM | 0.0418 mL | 0.2090 mL | 0.4180 mL | 1.0450 mL | |
| 60 mM | 0.0348 mL | 0.1742 mL | 0.3483 mL | 0.8708 mL | |
| 80 mM | 0.0261 mL | 0.1306 mL | 0.2612 mL | 0.6531 mL | |
| 100 mM | 0.0209 mL | 0.1045 mL | 0.2090 mL | 0.5225 mL |
GW 590735 Related Classifications
HY-106278 Related Classifications
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