Biological evaluation of novel benzisoxazole derivatives as PPARδ agonists

  • Bioorg Med Chem. 2011 May 15;19(10):3255-64. doi: 10.1016/j.bmc.2011.03.053.
Shogo Sakuma  1 ,  Tsuyoshi Endo ,  Takashi Kanda ,  Hideki Nakamura ,  Satomi Yamasaki ,  Tomio Yamakawa
Affiliations
  • 1. Discovery Research Laboratories, Nippon Chemiphar Co. Ltd, Hikokawado, Misato, Saitama, Japan. [email protected]
PMID: 21515063 DOI: 10.1016/j.bmc.2011.03.053
Abstract

We discovered novel Peroxisome Proliferator-activated Receptor δ agonists with a characteristic benzisoxazole ring. Compound 5 exhibited potent human PPARδ transactivation activity. Furthermore, it stimulated the differentiation of oligodendrocyte precursor cells in vitro. This indicates that this potential drug may be effective for the treatment of demyelinating disorders such as multiple sclerosis.