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Cat. No.: HY-155514

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HA-IN-1

HA-IN-1 (compound 5g) is a Hemagglutinin (HA) ligand with high affinity, targeting to the trypsin cleavage site of HA. HA-IN-1 inhibits HA-mediated membrane fusion and reduces the pulmonary virus titer in vivo. HA-IN-1 is a potential influenza A virus (IAV) inhibitor, and an anti-influenza agent.

For research use only. We do not sell to patients.

CAS No.: 3052340-42-5
Formula: C₄₂H₃₅NO₆
Molecular Weight:649.73

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

HA-IN-1 Chemical Structure

CAS No.: 3052340-42-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	CC₅₀	179.8 μM Compound: 5g	Cytotoxicity against human A549 cells assessed as cell viability measured after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as cell viability measured after 48 hrs by MTT assay	[PMID: 37413878]
MDCK	CC₅₀	>300 μM Compound: 5g	Cytotoxicity against dog MDCK cells assessed as cell viability measured after 48 hrs by MTT assay Cytotoxicity against dog MDCK cells assessed as cell viability measured after 48 hrs by MTT assay	[PMID: 37413878]
Vero	CC₅₀	1353 μM Compound: 5g	Cytotoxicity against african green monkey Vero cells assessed as cell viability measured after 48 hrs by MTT assay Cytotoxicity against african green monkey Vero cells assessed as cell viability measured after 48 hrs by MTT assay	[PMID: 37413878]

Chemical Information

CAS No. 3052340-42-5
Molecular Weight 649.73
Formula C₄₂H₃₅NO₆
SMILES

CC1=CC(C(C)=O)=C(O)C(CC2=C(CC3=C(O)C(C)=CC(C(C)=O)=C3O)C4=CC(C5=C6C(C=CC=C6)=CC7=C5C=CC=C7)=CC=C4N2)=C1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li B, et al. Design, synthesis, and biological evaluation of novel penindolone derivatives as potential inhibitors of hemagglutinin-mediated membrane fusion. Eur J Med Chem. 2023 Oct 5;258:115615. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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