1. Anti-infection
  2. Influenza Virus
  3. HA-IN-1

HA-IN-1 (compound 5g) is a Hemagglutinin (HA) ligand with high affinity, targeting to the trypsin cleavage site of HA. HA-IN-1 inhibits HA-mediated membrane fusion and reduces the pulmonary virus titer in vivo. HA-IN-1 is a potential influenza A virus (IAV) inhibitor, and an anti-influenza agent.

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HA-IN-1

HA-IN-1 Chemical Structure

CAS No. : 3052340-42-5

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Description

HA-IN-1 (compound 5g) is a Hemagglutinin (HA) ligand with high affinity, targeting to the trypsin cleavage site of HA. HA-IN-1 inhibits HA-mediated membrane fusion and reduces the pulmonary virus titer in vivo. HA-IN-1 is a potential influenza A virus (IAV) inhibitor, and an anti-influenza agent[1].

Cellular Effect
Cell Line Type Value Description References
A549 CC50
179.8 μM
Compound: 5g
Cytotoxicity against human A549 cells assessed as cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as cell viability measured after 48 hrs by MTT assay
[PMID: 37413878]
MDCK CC50
> 300 μM
Compound: 5g
Cytotoxicity against dog MDCK cells assessed as cell viability measured after 48 hrs by MTT assay
Cytotoxicity against dog MDCK cells assessed as cell viability measured after 48 hrs by MTT assay
[PMID: 37413878]
Vero CC50
1353 μM
Compound: 5g
Cytotoxicity against african green monkey Vero cells assessed as cell viability measured after 48 hrs by MTT assay
Cytotoxicity against african green monkey Vero cells assessed as cell viability measured after 48 hrs by MTT assay
[PMID: 37413878]
Molecular Weight

649.73

Formula

C42H35NO6

CAS No.
SMILES

CC1=CC(C(C)=O)=C(O)C(CC2=C(CC3=C(O)C(C)=CC(C(C)=O)=C3O)C4=CC(C5=C6C(C=CC=C6)=CC7=C5C=CC=C7)=CC=C4N2)=C1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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  • Molarity Calculator

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
HA-IN-1
Cat. No.:
HY-155514
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