2. Metabolic Enzyme/Protease
  3. HIF/HIF Prolyl-Hydroxylase
  4. HIF-1α-IN-2 hydrochloride

HIF-1α-IN-2 hydrochloride is an effective HIF-1α inhibitor with anticancer potencies (IC50s of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively). HIF-1α-IN-2 hydrochloride suppresses HIF-1α expression by blocking transcription and protein translation.

For research use only. We do not sell to patients.

HIF-1α-IN-2 hydrochloride Chemical Structure

HIF-1α-IN-2 hydrochloride Chemical Structure

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Based on 1 publication(s) in Google Scholar

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Description

HIF-1α-IN-2 hydrochloride is an effective HIF-1α inhibitor with anticancer potencies (IC50s of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively). HIF-1α-IN-2 hydrochloride suppresses HIF-1α expression by blocking transcription and protein translation[1].

Molecular Weight

397.92

Formula

C21H20ClN3OS
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC1=NC(C2=CC(NC3=CC(C)=NC4=CC(OC)=CC=C34)=CC=C2)=CS1.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation
References
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HIF-1α-IN-2 hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HIF-1α-IN-2HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHHypoxia-inducible factor-1αHIF-1αMigrationAnticancer agentDose-dependentMDA-MB-231MiaPaCa-2 cellsInhibitorinhibitorinhibit

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