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Cat. No.: HY-138865

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BiCAPPA

Name: BiCAPPA
Brand: MedChemExpress
SKU: HY-138865
Price: 260.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Based on 1 Customer Validation

BiCAPPA is the first bivalent antiprion ligand. BiCAPPA can decrease infectious conformational form of prion protein (PrP^Sc) from scrapie-infected cells, with an EC₅₀ of 0.32 μM.

For research use only. We do not sell to patients.

Purity: 98.35%
CAS No.: 119662-55-4
Formula: C₃₈H₄₀Cl₂N₆O₂
Molecular Weight:683.67

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

BiCAPPA Chemical Structure

CAS No.: 119662-55-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

HY-103706
ROC-325

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

BiCAPPA is the first bivalent antiprion ligand. BiCAPPA can decrease infectious conformational form of prion protein (PrP^Sc) from scrapie-infected cells, with an EC₅₀ of 0.32 μM^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	EC₅₀	1480 nM Compound: 9	Cytotoxicity against human HL60 cells Cytotoxicity against human HL60 cells	[PMID: 17371810]

In Vitro

BiCAPPA (10 nM-2 μM; 5 d) decreases proteinase K-resistant PrP^Sc from scrapie-infected mouse hypothalamus cells, with an EC₅₀ of 0.32 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 119662-55-4
Appearance Solid
Molecular Weight 683.67
Formula C₃₈H₄₀Cl₂N₆O₂
Color Yellow to orange
SMILES

ClC(C=CC1=C2NCCCN3CCN(CCCNC4=C5C=CC(Cl)=CC5=NC6=C4C=C(OC)C=C6)CC3)=CC1=NC7=C2C=C(OC)C=C7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 9.52 mg/mL (13.92 mM; ultrasonic and adjust pH to 4 with TFA; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.4627 mL

7.3135 mL

14.6269 mL

5 mM

0.2925 mL

1.4627 mL

2.9254 mL

10 mM

0.1463 mL

0.7313 mL

1.4627 mL

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Uliassi E, et, al. 10-Medicinal Chemistry of Hybrids for Neurodegenerative Diseases. Design of Hybrid Molecules for Drug Development. 2017, Pages 259-277.

[2]. Bongarzone S, et, al. Parallel synthesis, evaluation, and preliminary structure-activity relationship of 2,5-diamino-1,4-benzoquinones as a novel class of bivalent anti-prion compound. J Med Chem. 2010 Nov 25;53(22):8197-201. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.4627 mL	7.3135 mL	14.6269 mL	36.5674 mL
	5 mM	0.2925 mL	1.4627 mL	2.9254 mL	7.3135 mL
	10 mM	0.1463 mL	0.7313 mL	1.4627 mL	3.6567 mL

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
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CAS No.:
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BiCAPPA

Biological Activity

Description

Cellular Effect

In Vitro

Chemical Information

Solvent & Solubility

In Vitro:

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

BiCAPPA Related Classifications

HY-138865 Related Classifications

Bioz

Keywords

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