ML385 (Standard)
ML385 (Standard) is the analytical standard of ML385 (HY-100523). This product is intended for research and analytical applications. ML385 is a potent and selective Nrf2 inhibitor with an IC50 of 1.9 μM. ML385 directly binds to the Neh1 domain of NRF2, interferes with the binding of the MAFG-NRF2 protein complex to the antioxidant response element (ARE) DNA sequence, thereby blocking the expression of downstream target genes of NRF2. ML385 can be used in studies related to adult T-cell leukemia, breast cancer, myocardial ischemia/reperfusion injury, non-small cell lung cancer, esophageal squamous cell carcinoma, head and neck squamous cell carcinoma, and lung squamous cell carcinoma.
For research use only. We do not sell to patients.
- Purity : 98%
- CAS No.: 846557-71-9
- Formula: C29H25N3O4S
- Molecular Weight:511.59
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Product Information
-
Chemical Information
- Purity & Documentation
-
Help & FAQs
-
HY-100523
ML385Nrf2 Inhibitor -
HY-12212
OmaveloxoloneNrf2 Activator -
HY-19543
BrusatolNrf2 Inhibitor -
HY-13755
SulforaphaneKeap1/Nrf2/ARE Inducer -
HY-112675
4-Octyl itaconateNrf2 Activator -
HY-N1902
4-Hydroxyphenylacetic acidEndogenous Metabolite -
HY-101140
KI696KEAP1/NRF2 Protein-protein Interaction Inhibitor -
HY-12519
OltiprazHIF-1α Inhibitor -
HY-Z0548
Methyl 3,4-dihydroxybenzoate -
HY-N1902R
4-Hydroxyphenylacetic acid (Standard)Endogenous Metabolite -
HY-14909
BardoxoloneNrf2 Pathway Activator/SARS-CoV-2 3CLpro Inhibitor -
HY-N1913
DanshensuNrf2/HO-1 Activator
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
-
CAS No. 846557-71-9
-
Molecular Weight 511.59
-
Formula C29H25N3O4S
-
SMILES
O=C(NC1=NC(C2=CC=C(N(C(C3=C(C)C=CC=C3)=O)CC4)C4=C2)=C(C)S1)CC5=CC(OCO6)=C6C=C5
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ML385 (Standard) Related Classifications
HY-100523R Related Classifications
Powered by Bioz
Keywords
- ML385 (Standard)
- 846557-71-9
- Reference Standards
- Keap1-Nrf2
- Ferroptosis
- Apoptosis
- mTOR
- Mammalian target of Rapamycin
- Nrf2
- head and neck squamous cell carcinoma
- PBMCs
- Neh1 domain
- tamoxifen-resistant breast cancer
- lung squamous cell carcinoma
- esophageal squamous cell carcinoma
- Jurkat T cells
- non-small cell lung cancer
- adult T-cell leukemia
- Inhibitor
- inhibitor
- inhibit