Preclamol
Preclamol is a dopamine (DA) agonist with autoreceptor as well as postsynaptic receptor stimulatory properties. Preclamol inhibits the locomotor activity of mice and rats in low doses.
For research use only. We do not sell to patients.
- CAS No.: 85966-89-8
- Formula: C14H21NO
- Molecular Weight:219.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All Dopamine Receptor Isoforms
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
163 nM
Compound: (-)-3PPP
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Agonist activity at human D2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
Agonist activity at human D2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
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[PMID: 26555041] |
| CHO | EC50 |
376 nM
Compound: (-)-3PPP
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Antagonist activity against human D2 receptor expressed in CHO cells assessed as dopamine EC50 at 200 nM by [35S]GTPgammaS binding assay (Rvb = 225 +/- 45 nM)
Antagonist activity against human D2 receptor expressed in CHO cells assessed as dopamine EC50 at 200 nM by [35S]GTPgammaS binding assay (Rvb = 225 +/- 45 nM)
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[PMID: 26555041] |
| CHO | EC50 |
51.9 nM
Compound: (-)-3PPP
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Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
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[PMID: 26555041] |
| CHO | EC50 |
844 nM
Compound: (-)-3PPP
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Antagonist activity against human D2 receptor expressed in CHO cells assessed as dopamine EC50 at 1 uM by [35S]GTPgammaS binding assay (Rvb = 225 +/- 45 nM)
Antagonist activity against human D2 receptor expressed in CHO cells assessed as dopamine EC50 at 1 uM by [35S]GTPgammaS binding assay (Rvb = 225 +/- 45 nM)
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[PMID: 26555041] |
Chemical Information
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CAS No. 85966-89-8
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Molecular Weight 219.32
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Formula C14H21NO
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SMILES
CCCN1C[C@H](C2=CC(O)=CC=C2)CCC1
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Synonyms
(-)-3-PPP
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Protocol for Open Field Test (OF)
The Open Field Test is a rodent behavioral assay that measures spontaneous locomotion, exploratory behavior, and anxiety-like behavior when an animal is placed in a novel open arena. The main readouts are total distance traveled, movement time, velocity, center-zone entries, center-zone time, peripheral-zone time, and thigmotaxis. The assay is based on the conflict between exploration of a novel environment and avoidance of exposed open areas; higher center exploration is commonly interpreted as lower anxiety-like behavior, whereas increased wall-following or peripheral occupancy is interpreted as higher anxiety-like behavior.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Preclamol Related Classifications
HY-145454A Related Classifications
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