Hordenine (Standard)
Hordenine (Standard) (Ordenina (Standard); Peyocactine (Standard)) is the analytical standard of Hordenine (HY-N0113). This product is intended for research and analytical applications. Hordenine (Ordenina; Peyocactine) is a multifunctional alkaloid with oral activity and blood-brain barrier penetration. Hordenine inhibits LPS-induced phosphorylation of p38, JNK, ERK1/2, p65, IκB, and AKT, prevents p65 nuclear translocation, and suppresses inflammatory cytokines and mediators. Hordenine promotes M2 macrophage polarization, restores blood-milk barrier integrity, alleviates oxidative stress by reducing ROS and MDA, and attenuates LPS-induced lung injury and pulmonary edema. Hordenine inhibits cAMP production, CREB phosphorylation, and MITF expression, thereby suppressing melanin synthesis in melanocytes and reconstructed epidermis. Hordenine activates the Wnt/β-catenin signaling pathway, promotes dermal papilla cell proliferation and hair shaft elongation, and accelerates hair regeneration. Hordenine activates DRD2, acts as a D3R partial agonist, α2A-AR full agonist, and 5-HT2A-R antagonist, and inhibits SERT and DAT. Hordenine inhibits α-synuclein accumulation and ameliorates motor deficits in Parkinson's disease models. Hordenine limits alcohol intake, reduces relapse drinking behavior, and modulates alcohol-induced conditioned place preference. Hordenine can be used for research on mastitis, skin pigmentation, acute lung injury, foodborne diseases, hair loss, Parkinson's disease, bacterial infections, and alcohol use disorder.
For research use only. We do not sell to patients.
- Purity : 98%
- CAS No.: 539-15-1
- Formula: C₁₀H₁₅NO
- Molecular Weight:165.23
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Product Information
-
Chemical Information
- Purity & Documentation
-
Help & FAQs
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
-
CAS No. 539-15-1
-
Molecular Weight 165.23
-
Formula C₁₀H₁₅NO
-
SMILES
OC1=CC=C(CCN(C)C)C=C1
-
Synonyms
Ordenina (Standard); Peyocactine (Standard)
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[2]. Kim SC, et al. Hordenine, a single compound produced during barley germination, inhibits melanogenesis in human melanocytes. Food chemistry. 2013 Nov 01;141(1):174-81. [Content Brief]
[6]. Li H, et al. Hordenine improves Parkinsonian-like motor deficits in mice and nematodes by activating dopamine D2 receptor-mediated signaling. Phytotherapy research : PTR. 2023 Aug;37(8):3296-3308. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hordenine (Standard) Related Classifications
HY-N0113R Related Classifications
Powered by Bioz
Keywords
- Hordenine (Standard)
- 539-15-1
- Ordenina (Standard)
- Peyocactine (Standard)
- Reference Standards
- Bacterial
- p38 MAPK
- JNK
- ERK
- Akt
- Interleukin Related
- TNF Receptor
- NO Synthase
- COX
- Reactive Oxygen Species (ROS)
- Microphthalmia Associated Transcription Factor (MITF)
- Wnt
- β-catenin
- Dopamine Receptor
- Adrenergic Receptor
- 5-HT Receptor
- Serotonin Transporter
- Dopamine Transporter
- α-synuclein
- TRP-1
- tyrosinase
- MITF
- cAMP
- Nrf2
- HO-1
- TLR4
- NF-κB
- AMPK
- MAPK
- Inhibitor
- inhibitor
- inhibit