Hydroxyectoin
Based on 1 Customer Validation
Hydroxyectoin (Pyrostatin A) is a natural substance that acts as a cytoprotective agent. Hydroxyectoin can be used in research related to Alzheimer's disease.
For research use only. We do not sell to patients.
- Purity: 98.92%
- CAS No.: 165542-15-4
- Formula: C6H10N2O3
- Molecular Weight:158.16
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Hydroxyectoin exhibits superior glass-forming properties with a glass transition temperature of 87 °C, making it an effective desiccation protectant for biomolecules and cells[2].
Hydroxyectoin increases the melting temperature of DNA, distinguishing its effect on DNA stability from that of Ectoine (HY-107784)[2].
Hydroxyectoin (0.5-1.0 M; 4 cycles of fast freezing/slow defrosting) preserves the activity of purified lactate dehydrogenase, glutamate dehydrogenase, carboxylesterase, and CD30 binding protein under freeze-thaw stress, with 1.0 M maintaining full lactate dehydrogenase activity and 0.5 M maintaining full carboxylesterase activity[3].
Hydroxyectoin (0.1-2.0 M) preserves the activity of multiple purified proteins under elevated temperature stress, with 1.0 M maintaining full phosphofructokinase activity and 0.5 M maintaining active monoclonal antibodies and 90% lactate dehydrogenase activity[3].
Hydroxyectoin (0.4-1.0 M) preserves the activity of purified phosphofructokinase and enolase under freeze-drying stress, with 0.4 M maintaining 97% enolase activity[3].
Hydroxyectoin (3.0 M) increases the melting temperature of purified RNase A by 12 K, enhancing its thermal stability[3].
Hydroxyectoin protects Pseudomonas putida and Escherichia coli against desiccation, enhancing cell survival and stability after drying[3].
Hydroxyectoin induces thermotolerance in Escherichia coli, enhancing its survival under high temperature stress[3].
Hydroxyectoin protects recombinant proteins and immunotoxins against multiple stressors including degradation, aggregation, conformational change, and freeze-thaw damage in vitro[3].
Hydroxyectoin increases the melting temperature of purified DNA and improves the quality of DNA microarrays in vitro[3].
Hydroxyectoin (0.5 M) preserves 95% of purified lactate dehydrogenase activity under oxidative stress from H2O2[3].
Hydroxyectoin (Pyrostatin A) inhibits aggregation and neurotoxicity of Alzheimer's Aβ42 peptide in vitro[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 165542-15-4
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Appearance Solid
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Molecular Weight 158.16
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Formula C6H10N2O3
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Color White to light yellow
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SMILES
OC([C@@H]1[C@H](CN=C(C)N1)O)=O
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Synonyms
Pyrostatin A; 5-Hydroxyectoine
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Structure Classification
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Initial Source
Streptomyces sp.
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 50 mg/mL (316.14 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (288 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 6.3227 mL | 31.6136 mL | 63.2271 mL | 158.0678 mL |
| 5 mM | 1.2645 mL | 6.3227 mL | 12.6454 mL | 31.6136 mL | |
| 10 mM | 0.6323 mL | 3.1614 mL | 6.3227 mL | 15.8068 mL | |
| 15 mM | 0.4215 mL | 2.1076 mL | 4.2151 mL | 10.5379 mL | |
| 20 mM | 0.3161 mL | 1.5807 mL | 3.1614 mL | 7.9034 mL | |
| 25 mM | 0.2529 mL | 1.2645 mL | 2.5291 mL | 6.3227 mL | |
| 30 mM | 0.2108 mL | 1.0538 mL | 2.1076 mL | 5.2689 mL | |
| 40 mM | 0.1581 mL | 0.7903 mL | 1.5807 mL | 3.9517 mL | |
| 50 mM | 0.1265 mL | 0.6323 mL | 1.2645 mL | 3.1614 mL | |
| 60 mM | 0.1054 mL | 0.5269 mL | 1.0538 mL | 2.6345 mL | |
| 80 mM | 0.0790 mL | 0.3952 mL | 0.7903 mL | 1.9758 mL | |
| 100 mM | 0.0632 mL | 0.3161 mL | 0.6323 mL | 1.5807 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Hydroxyectoin Related Classifications
HY-108032 Related Classifications
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