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Cat. No.: HY-119860

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Ataprost

(Synonyms: ONO 41483)

Ataprost (ONO 41483) is an orally active Carboprostacyclin (HY-112322) analogue. Ataprost exhibits 2.6 times more active than Carboprostacyclin in inhibiting ADP-induced platelet aggregation in vitro. Ataprost has the ability to relieve coronary spasm.

For research use only. We do not sell to patients.

CAS No.: 83997-19-7
Formula: C₂₁H₃₂O₄
Molecular Weight:348.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Ataprost Chemical Structure

CAS No.: 83997-19-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Platelet aggregation^[1]

In Vitro

Ataprost inhibits platelet aggregation in human and baboon platelet rich plasma (PRP) with ED₅₀s of 1.91 ng/mL and 4.38 ng/mL, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ataprost (50-200 μg/kg; p.o.; single dose) inhibits platelet aggregation with an ED₅₀ value of 87 μg/kg in baboon^[1].
Ataprost (i.v.; single dose) inhibits platelet aggregation with an ED₅₀ value of 3.2 μg/kg in baboon^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 83997-19-7
Molecular Weight 348.48
Formula C₂₁H₃₂O₄
SMILES

O[C@@H](C1CCCC1)/C=C/[C@@H]2[C@](C/3)([H])[C@](CC3=C/CCCC(O)=O)([H])C[C@H]2O
Synonyms

ONO 41483
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Adaikan PG, et al. Inhibition of platelet aggregation and reversal of vasopressin-induced ECG changes by a carboprostacyclin analogue, ONO 41483, in primates. Prostaglandins Leukot Med. 1982 Sep;9(3):307-20. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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