Dazukibart
Based on 1 Customer Validation
Dazukibart (PF‑06823859) is a humanized IgG1 monoclonal antibody targeting IFN‑β that binds to and neutralizes IFN-β. Dazukibart can be used in research on autoimmune inflammatory diseases such as dermatomyositis.
For research use only. We do not sell to patients.
- Purity : 99.9%
- CAS No.: 2639474-65-8
- Molecular Weight:145.36 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
IFNB1
In Vitro
Dazukibart neutralizes IFN-β and inhibits downstream type I interferon-dependent inflammatory signaling[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG1 kappa
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized Animal-Free IFN-beta Protein, Human (His, HY-P700090AF) can bind Dazukibart. The EC50 for this effect is 11.01 ng/mL.
Chemical Information
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CAS No. 2639474-65-8
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Appearance Liquid
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Molecular Weight 145.36 kDa
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Color Colorless to light yellow
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SMILES
[Dazukibart]
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Synonyms
PF-06823859
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (266 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)