UXT - ubiquitously expressed prefoldin like chaperone Gene

Also Known as STAP1; ART-27

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8409

About UXT

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:47,651,796-47,659,180 (from NCBI)

This gene has 5 transcripts (splice variants) and 181 orthologues. Ubiquitous expression in bone marrow (RPKM 37.8), ovary (RPKM 37.2) and 25 other tissues.

Summary

The protein encoded by this gene functions as a cofactor that modulates androgen receptor-dependent transcription, and also plays a critical role in tumor necrosis factor-induced Apoptosis. Expression of this gene may play a role in tumorigenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

UXT Products (2)

mRNA Protein Name
NM_004182.4 NP_004173.1 protein UXT isoform 2
NM_153477.3 NP_705582.1 protein UXT isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables actin filament binding IDA
IDA: Inferred from direct assay
12762840 GOA
enables beta-tubulin binding IDA
IDA: Inferred from direct assay
12762840 GOA
enables chromatin binding IDA
IDA: Inferred from direct assay
21730289 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12762840 GOA
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
21730289 GOA
Biological Process GO Annotation Evidence References Source
involved in centrosome cycle IMP
IMP: Inferred from mutant phenotype
16221885 GOA
involved in microtubule cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
16221885 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
21730289 GOA
Cellular Component GO Annotation Evidence References Source
part of RPAP3/R2TP/prefoldin-like complex IPI
IPI: Inferred from physical interaction
31738558 GOA
located in centrosome IDA
IDA: Inferred from direct assay
16221885 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
21730289 GOA
located in cytoskeleton IDA
IDA: Inferred from direct assay
12762840 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12762840 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UXT Protein Structure

Prefoldin

Prefoldin: Prefoldin subunit (29 - 146)

  • 0
  • 100
  • 157 a.a.
Protein Preferred Names Protein Names

protein UXT

  • SKP2-associated alpha PFD 1

UXT Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UXT Q9UBK9 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
25416956
Intra
UXT Q9UBK9 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra
UXT Q9UBK9 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra
UXT Q9UBK9 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
UXT Q9UBK9 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
UXT Q9UBK9 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
25416956
Intra
UXT Q9UBK9 KRTAP10-7 Homo sapiens P60409
Validated Y2H
25416956
Intra
UXT Q9UBK9 KRTAP10-7 Homo sapiens P60409
Y2H Array
25416956
Intra
UXT Q9UBK9 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra
UXT Q9UBK9 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra
UXT Q9UBK9 DYNLT1 Homo sapiens P63172
Y2H Prey Pooling
32296183
Intra
UXT Q9UBK9 DYNLT1 Homo sapiens P63172
Y2H Array
32296183
Intra
UXT Q9UBK9 KRTAP12-3 Homo sapiens P60328
Y2H Array
32296183
Intra
UXT Q9UBK9 KRTAP12-3 Homo sapiens P60328
Y2H Prey Pooling
32296183
Intra
UXT Q9UBK9 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Array
32296183
Intra
UXT Q9UBK9 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Prey Pooling
32296183
Intra
UXT Q9UBK9 MECOM Homo sapiens Q03112
Y2H
17635584
Intra
UXT Q9UBK9 MECOM Homo sapiens Q03112
Pull Down
17635584
Intra
UXT Q9UBK9 MECOM Homo sapiens Q03112
Anti Tag CoIP
17635584
Intra
UXT Q9UBK9 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
UXT Q9UBK9 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
UXT Q9UBK9 RPAP3 Homo sapiens Q9H6T3
Anti Tag CoIP
33961781
Intra
UXT Q9UBK9 RPAP3 Homo sapiens Q9H6T3
Lumier
25036637
Intra
UXT Q9UBK9 PFDN2 Homo sapiens Q9UHV9
Lumier
25036637
Intra
UXT Q9UBK9 KRTAP5-9 Homo sapiens P26371
Y2H Array
32296183
Intra
UXT Q9UBK9 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
32296183
Intra
UXT Q9UBK9 RELA Homo sapiens Q04206
Anti Bait CoIP
17620405
Intra
UXT Q9UBK9 PAK5 Homo sapiens Q9P286
Y2H Prey Pooling
25416956
Intra
UXT Q9UBK9 PAK5 Homo sapiens Q9P286
Y2H Array
31515488
Intra
UXT Q9UBK9 PAK5 Homo sapiens Q9P286
Y2H Array
25416956
Intra
UXT Q9UBK9 SIAH1 Homo sapiens Q8IUQ4
Y2H Prey Pooling
25416956
Intra
UXT Q9UBK9 SIAH1 Homo sapiens Q8IUQ4
Validated Y2H
25416956
Intra
UXT Q9UBK9 SARM1 Homo sapiens Q0D2N8
Y2H
24021647
Intra
UXT Q9UBK9 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
31515488
Intra
UXT Q9UBK9 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
Intra
UXT Q9UBK9 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
UXT Q9UBK9 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15591 UXT Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus UXT VGNC VGNC:36754
Felis catus UXT VGNC VGNC:66910
Rattus norvegicus UXT RGD RGD:1359326
Macaca mulatta UXT VGNC VGNC:103884
Canis familiaris UXT VGNC VGNC:48221
Mus musculus UXT MGD MGI:1277988
Others UXT NCBI