PSI-112
PSI-112 is a YO-class μPlm inhibitor, with IC50 values of 0.38 μM, 1.48 μM and 0.37 μM against the wild-type, F587A mutant and K607A mutant, respectively. PSI-112 shows low affinity for uPA. PSI-112 can be used in cancer research.
For research use only. We do not sell to patients.
- CAS No.: 1854997-77-5
- Formula: C35H48N4O3
- Molecular Weight:572.78
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
μPlm 0.38 μM (IC50) |
In Vitro
PSI-112 inhibits wild-type μPlm with an IC50 of 0.38 μM, and its affinity for uPA (IC50 >25 μM) is lower than that for μPlm[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1854997-77-5
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Molecular Weight 572.78
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Formula C35H48N4O3
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SMILES
O=C([C@@H]1CC[C@H](CC1)CN)N[C@H](C(NCCCCCCCC)=O)CC(C=C2)=CC=C2OCC3=NC4=C(C=CC=C4)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PSI-112 Related Classifications
HY-182565 Related Classifications
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