VK-28
Based on 1 Customer Validation
VK-28 is a blood-brain barrier-permeable iron chelator. VK-28 inhibits mitochondrial membrane lipid peroxidation and the iron-dependent generation of reactive hydroxyl radicals. VK-28 exhibits neuroprotective activity and protects rats against 6-OHDA-induced striatal dopaminergic damage. VK-28 can be used in studies related to Parkinson's disease.
For research use only. We do not sell to patients.
- Purity: 97.17%
- CAS No.: 312611-92-0
- Formula: C16H21N3O2
- Molecular Weight:287.36
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
VK-28 (10-7-10-3 M; 90 min) potently inhibits basal lipid peroxidation and iron-induced lipid peroxidation in mitochondrial membrane homogenates from rat cerebral cortex, with an IC50 of 12.7 µM[1].
VK-28 (1-10 μM; 24 h) exhibits neuroprotective activity by reducing serum deprivation-induced PC12 cell death[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC12 cells
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Concentration:1 μM, 10 μM
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Incubation Time:24 h
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Result:Rescued PC12 cells from serum-free induced death, resulting in ~1000% of control OD at 1 μM and ~900% of control OD at 10 μM.
Reduced cell death compared to untreated serum-free cells.
Showed neuroprotective activity comparable to rasagiline.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (male, 230-270 g, 8-10 per group, intracerebroventricular 6-hydroxydopamine-induced striatal dopaminergic lesion)[1]
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Dosage:1 µg
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Administration:i.c.v.; single dose (30 minutes before 6-OHDA)
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Result:Prevented the 78% reduction in striatal dopamine (DA), 73% reduction in dihydroxyphenylacetic acid (DOPAC), and 59% reduction in homovanilic acid (HVA) caused by 6-OHDA alone.
Reduced the 6-OHDA-induced increase in striatal dopamine turnover ratio (DOPAC+HVA/DA) to near baseline levels.
Left striatal serotonin (5-HT), 5-hydroxyindolacetic acid (5-HIAA), and norepinephrine (NE) concentrations unaffected.
Chemical Information
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CAS No. 312611-92-0
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Appearance Solid
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Molecular Weight 287.36
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Formula C16H21N3O2
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Color White to off-white
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SMILES
OCCN1CCN(CC1)CC2=C3C=CC=NC3=C(C=C2)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Shachar DB, et al. Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in rats. Neuropharmacology. 2004;46(2):254-263. [Content Brief]
[2]. Youdim MB, et al. Bifunctional drug derivatives of MAO-B inhibitor rasagiline and iron chelator VK-28 as a more effective approach to treatment of brain ageing and ageing neurodegenerative diseases. Mech Ageing Dev. 2005;126(2):317-326. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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