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Cat. No.: HY-142287

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Con B-1

ConB-1 is a potent and selective ALK inhibitor with low toxicity to normal cells.

For research use only. We do not sell to patients.

CAS No.: 2415537-51-6
Formula: C₃₈H₅₂ClN₇O₆S
Molecular Weight:770.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

Con B-1 Chemical Structure

CAS No.: 2415537-51-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

ConB-1 is a potent and selective ALK inhibitor with low toxicity to normal cells^[1].

IC₅₀ & Target

ALK^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H3122	IC₅₀	0.15 μM Compound: Con B-1	Antiproliferative activity against human NCI-H3122 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-H3122 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33471528]

Chemical Information

CAS No. 2415537-51-6
Molecular Weight 770.38
Formula C₃₈H₅₂ClN₇O₆S
SMILES

C=CC(NCCOCCNC(CCN1CCC(CC1)C2=CC(OC(C)C)=C(C=C2C)NC3=NC(NC4=C(C=CC=C4)S(=O)(C(C)C)=O)=C(C=N3)Cl)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yan G, et al. Targeting Cysteine Located Outside the Active Site: An Effective Strategy for Covalent ALKi Design. J Med Chem. 2021 Feb 11;64(3):1558-1569. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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