CDNF
Cerebral dopamine neurotrophic factor (CDNF) is a secreted, endoplasmic reticulum (ER)-resident protein and, together with MANF, one of only two members of the CDNF/MANF family of neurotrophic factors. Its architecture pairs an N-terminal saposin-like lipid-binding domain with a C-terminal domain that carries a KDEL-like ER-retention sequence and interacts with the chaperone BiP. Unlike classical neurotrophic factors, CDNF does not act through a dedicated high-affinity tyrosine kinase receptor; instead it is taken up by cells, relieves ER stress and supports the survival of dopaminergic neurons. Recombinant CDNF shows neuroprotective and restorative effects in rodent and primate models of Parkinson's disease and has entered clinical evaluation.
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CDNF Recombinant Proteins (5)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
