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製品番号: HY-182568

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Iocarmic acid

Iocarmic acid is a myelographic contrast agent. Iocarmic acid is used for lumbar nerve root angiography and ventriculography. Iocarmic acid induces arachnoiditis via lumbar subarachnoid injection. Iocarmic acid can be used for the research of arachnoiditis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 10397-75-8
分子式: C₂₄H₂₀I₆N₄O₈
分子量:1253.86

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Iocarmic acid 構造式

CAS 番号: 10397-75-8

価格（税別）

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体内実験

Iocarmic acid (1.2 mL of 282 mg I/mL; intrathecal; single injection) induces severe arachnoiditis in macaque monkeys undergoing experimental myelography, with maximum myelographic scores and an average histologic score of 18, which is significantly higher than scores for comparator contrast media and controls^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Macaque monkeys (5-7 kg)^[1]
Dosage:

1.2 mL of 282 mg I/mL
Administration:

intrathecal; single injection
Result:

Induced a consistent myelographic arachnoiditis score of 36 (maximum possible score) across all 4 animals tested.
Produced an average histologic arachnoiditis score of 18, with individual scores ranging from 12 to 20.
Resulted in scores significantly higher than scores for iopamidol, metrizamide, and CSF controls (P < 0.05, Wilcoxon test).

化学情報

CAS 番号 10397-75-8
分子量 1253.86
分子式 C₂₄H₂₀I₆N₄O₈
SMILES

O=C(C1=C(C(NC(CCCCC(NC2=C(I)C(C(NC)=O)=C(I)C(C(O)=O)=C2I)=O)=O)=C(C(C(NC)=O)=C1I)I)I)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Haughton VM, et al. Arachnoiditis from myelography with iopamidol, metrizamide, and iocarmate compared in the animal model. Invest Radiol. 1980 Nov-Dec;15(6 Suppl):S267. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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