1. IRAK
  2. IRAK inhibitor 6

IRAK inhibitor 6 

Cat. No.: HY-13280 Purity: 99.75%
Handling Instructions

IRAK inhibitor 6 is an inhibitor of interleukin-1 receptor associated kinase 4 (IRAK-4) with IC50 of 160 nM.

For research use only. We do not sell to patients.

IRAK inhibitor 6 Chemical Structure

IRAK inhibitor 6 Chemical Structure

CAS No. : 1042672-97-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 319 In-stock
Estimated Time of Arrival: December 31
5 mg USD 290 In-stock
Estimated Time of Arrival: December 31
10 mg USD 396 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1030 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

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Description

IRAK inhibitor 6 is an inhibitor of interleukin-1 receptor associated kinase 4 (IRAK-4) with IC50 of 160 nM.

IC50 & Target

IC50: 160 nM (IRAK-4)[1]

In Vitro

IRAK inhibitor 6 significantly improves potency against IRAK-4. Potency effects additive, IRAK inhibitor 6 is the most active compound among these compound tested[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

396.46

Formula

C₂₀H₂₀N₄O₃S

CAS No.

1042672-97-8

SMILES

COC1=CC(N2CCOCC2)=CC=C1NC(C3=CSC(C4=CC=CN=C4)=N3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (21.01 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5223 mL 12.6116 mL 25.2232 mL
5 mM 0.5045 mL 2.5223 mL 5.0446 mL
10 mM 0.2522 mL 1.2612 mL 2.5223 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.83 mg/mL (2.09 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

IRAK inhibitor 6IRAK inhibitor6IRAK inhibitor-6IRAKInterleukin-1 receptor associated kinaseIL-1R associated kinaseInhibitorinhibitorinhibit

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Product Name:
IRAK inhibitor 6
Cat. No.:
HY-13280
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