ADTL-EI1712
ADTL-EI1712 is a potent, orally active, and selective dual-target inhibitor of ERK1 and ERK5, inhibition rates of ERK1/5 at 1 μM are 93.54% and 89.35%, respectively. ADTL-EI1712 can induce regulated cell death, a form of cell death that relies on the activation of genetically encoded machinery, to overcome compensatory mechanism in specific cancer cells in vitro and in vivo.
For research use only. We do not sell to patients.
- CAS No.: 2414916-45-1
- Formula: C22H18Cl2N4O2S2
- Molecular Weight:505.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
>50 μM
Compound: 22ac; ADTL-EI1712
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Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs
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[PMID: 32078308] |
| HL-60 | IC50 |
1.26 μM
Compound: 22ac; ADTL-EI1712
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Antiproliferative activity against human HL60 cells assessed as reduction in cell viability measured after 24 hrs
Antiproliferative activity against human HL60 cells assessed as reduction in cell viability measured after 24 hrs
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[PMID: 32078308] |
| MKN-74 | IC50 |
2.55 μM
Compound: 22ac; ADTL-EI1712
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Antiproliferative activity against human MKN74 cells assessed as reduction in cell viability measured after 24 hrs
Antiproliferative activity against human MKN74 cells assessed as reduction in cell viability measured after 24 hrs
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[PMID: 32078308] |
ADTL-EI1712 shows antiproliferative activity against HL-60, MKN-74 and HeLa cells, with IC50 values of 1.26+0.57, 2.55+0.66, >50 μM, respectively[1].
ADTL-EI1712 (0.5 μM, 24 h) induces regulated cell death accompanied by autophagy in MKN-74 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2414916-45-1
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Molecular Weight 505.44
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Formula C22H18Cl2N4O2S2
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SMILES
O=C(C1=C(NC(C2=CC=CC=C2Cl)=O)SC3=C1CCN(C(NC4=CC=CC=C4Cl)=S)C3)N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ADTL-EI1712 Related Classifications
HY-138215 Related Classifications
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