Brigatinib C
Based on 1 Customer Validation
Brigatinib C is a prodrug of ALK inhibitor, which can be used to syntheis PROTACs.
For research use only. We do not sell to patients.
- Purity: 99.72%
- CAS No.: 1197958-75-0
- Formula: C28H37ClN7O2P
- Molecular Weight:570.07
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
|
EGFR |
FAK |
PYK2 |
PTK6 |
|
Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SR | IC50 |
6.8 nM
Compound: Brigatinib C
|
Antiproliferative activity against human SR cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human SR cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
|
[PMID: 34138566] |
| SR | IC50 |
6.8 nM
Compound: 3
|
Antiproliferative activity against human SR cells assessed as reduction in cell growth
Antiproliferative activity against human SR cells assessed as reduction in cell growth
|
[PMID: 32179332] |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1197958-75-0
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Appearance Solid
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Molecular Weight 570.07
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Formula C28H37ClN7O2P
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Color Off-white to light brown
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SMILES
COC1=CC(N2CCC(CC2)N3CCNCC3)=CC=C1NC4=NC=C(C(NC5=CC=CC=C5P(C)(C)=O)=N4)Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (266 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)