Elarekibep
Based on 1 Customer Validation
Elarekibep (PRS-060) (AZD1402) is a high affinity, slowly dissociating, long-acting full antagonist of IL-4Ra. Elarekibep can be used for the research of T2 endotype asthma.
For research use only. We do not sell to patients.
- Purity : 98.86%
- CAS No.: 2485020-60-6
- Molecular Weight:16.99 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Species Reactivity
Human
IC50 & Target
IL-4Ra/CD124
In Vitro
Elarekibep (PRS-060) (0-10 µM) inhibits IL-4- or IL-13-induced STAT-6 phosphorylation with IC50 values of 0.12 nM and 0.10 nM, respectively[1].
PRS-060 (0-10 µM) inhibits hIL-4 or hIL-13 indued proliferation of TF-1 cells with IC50 values of 0.87 nM and 0.92 nM, respectively[1].
PRS-060 (0-10 µM) inhibits hIL-13 induced human epithelial cell mucus transdifferentiation with an IC50 value of 0.3 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Triple-humanized mouse model[1]
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Dosage:2, 10, 50 µg/mouse
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Administration:Intratracheal instillation (i.t)
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Result:Strongly suppressed acute allergic inflammation indices in triple humanized mice.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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LCN1 (lipocalin 1) fragment (1-154)
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized Elarekibep can bind Human IL-4R Protein (ECD, His Tag). The EC50 for this effect is 13.96 ng/mL. -
Flow cytometric analysis of 1.5×106 Ramos cells labeling Elarekibep (HY-P99935, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control.
Chemical Information
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CAS No. 2485020-60-6
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Appearance Liquid
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Molecular Weight 16.99 kDa
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Color Colorless to light yellow
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SMILES
[Elarekibep]
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Synonyms
PRS-060; AZD1402
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (259 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)