CNN1 - calponin 1 Gene

Also Known as SMCC; Sm-Calp; HEL-S-14

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1264

About CNN1

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:11,538,851-11,550,323 (from NCBI)

This gene has 10 transcripts (splice variants), 222 orthologues and 5 paralogues. Biased expression in urinary bladder (RPKM 288.3), endometrium (RPKM 280.5) and 11 other tissues.

Summary

Predicted to enable actin binding activity. Involved in negative regulation of vascular associated smooth muscle cell proliferation. Located in Cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]

CNN1 Products (3)

mRNA Protein Name
NM_001299.6 NP_001290.2 calponin-1 isoform 1
NM_001308341.2 NP_001295270.1 calponin-1 isoform 2
NM_001308342.2 NP_001295271.1 calponin-1 isoform 2

CNN1 Protein Structure

CH

CH: Calponin homology (CH) domain (31 - 130)

Calponin

Calponin: Calponin family repeat (164 - 189)

Calponin

Calponin: Calponin family repeat (204 - 228)

Calponin

Calponin: Calponin family repeat (244 - 268)

  • 0
  • 100
  • 200
  • 297 a.a.
Protein Preferred Names Protein Names

calponin-1

  • basic calponin

CNN1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CNN1 P51911 TFPT Homo sapiens P0C1Z6
BFG-2H
27107012
Intra
CNN1 P51911 TFPT Homo sapiens P0C1Z6
Validated Y2H
27107012
Cross: Cross-species interaction Intra: Intraspecies interaction

CNN1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81094 Calponin 1 Antibody (YA3487) WB, IHC-P, ICC/IF Human, Mouse, Rat
HY-P85838 Calponin-1 Antibody (YA5530) IHC-P, WB, ICC/IF, ELISA Human
HY-P86192 Calponin-1 Antibody (YA5884) WB, IHC-P, ICC/IF, IP, ELISA Human, Mouse, Rat
HY-P86685 Calponin-1 Antibody (YA6377) WB, IHC-P, IF-Tissue, IHC-F Human, Mouse, Rat

Related Diseases

Diseases Alias
Subareolar Duct Papillomatosis

  • Adenoma Of The Nipple
Nipple Benign Neoplasm

  • Tumor Of Nipple
Marfan Syndrome

  • MFS

  • Mfs1

  • Marfan'S Syndrome

  • Marfan Syndrome Type 1

  • Marfan Syndrome, Type I

  • Mass Phenotype

  • Contractural Arachnodactyly

  • Mass Syndrome

  • Octd

  • Overlap Connective Tissue Disease

  • Marfanoid Hypermobility Syndrome

  • Marfan Disease
Osteogenesis Imperfecta, Type Xv

  • Osteogenesis Imperfecta Type 15

  • OI15

  • Osteogenesis Imperfecta Type Xv

  • Oi, Type Xv

  • Osteogenesis Imperfecta 15

  • Oi Type Xv

  • Oi-Xv
Aortic Valve Disease 1

  • Aortic Valve Disease

  • Bicuspid Aortic Valve

  • Aortic Valve Disorder

  • AOVD1

  • Bav

  • Bicuspid Aortic Valve Disease

  • Familial Bicuspid Aortic Valve

  • Aortic Valve Calcification

  • Aovd

  • Aortic Valve, Bicuspid

  • Aortic Valve, Calcification Of

  • Aortic Stenosis, Calcific

  • Familial Bav

  • Calcific Aortic Stenosis

  • Calcification Of Aortic Valve

  • Abnormality Of The Aortic Valve

  • Aortic Valve Disease, Type 1

  • Aortic Valve Disease 2

  • Bicommissural Aortic Valve
Supravalvular Aortic Stenosis

  • SVAS

  • Supravalvar Aortic Stenosis

  • Supravalvar Aortic Stenosis, Eisenberg Type

  • Aortic Supravalvular Stenosis

  • Aortic Stenosis, Supravalvular

  • Supra-Valvular Aortic Stenosis

  • Stenosis, Aortic Supravalvular

  • Stenosis, Supravalvular Aortic

  • Supravalvular Stenosis, Aortic

  • Aortic Stenosis Supravalvular
Aortic Dissection
Aortic Aneurysm, Familial Thoracic 1

  • Thoracic Aortic Aneurysm

  • Annuloaortic Ectasia

  • Familial Thoracic Aortic Aneurysm And Aortic Dissection

  • Familial Aortic Dissection

  • Familial Taad

  • Familial Thoracic Aortic Aneurysm

  • Congenital Aneurysm Of Ascending Aorta

  • Familial Aortic Aneurysm

  • Familial Thoracic Aortic Aneurysm And Dissection

  • Aortic Aneurysm, Thoracic

  • AAT1

  • Faa1

  • Aortic Dissection, Familial

  • Aortic Aneurysm, Familial Thoracic

  • Aneurysm, Thoracic Aortic

  • Faa

  • Ftaad

  • Taa

  • Taad

  • Cystic Medial Necrosis Of Aorta

  • Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection

  • Aortic Aneurysm Thoracic

  • Familial Aortic Aneurysms

  • Aneurysm, Aortic, Thoracic, Familial, Type 1

  • Aneurysm Of Thoracic Aorta

  • Intrathoracic Aneurysm

  • Thoracic Aorta Aneurysm

  • Thoracic Aortic Aneurysm Without Rupture

  • Thoracic Aneurysm

  • Thorax Arterial Aneurysm

  • Thoracic Artery Aneurysm

  • Thoracic Arterial Aneurysm

  • Thorax Aneurysm

  • Thorax Aortic Aneurysm

  • Dissection Of Thoracic Aorta
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02892 CNN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22127 Cnn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28649 Cnn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CNN1 MGD MGI:104979
Bos taurus CNN1 VGNC VGNC:27508
Canis familiaris CNN1 VGNC VGNC:57306
Felis catus CNN1 VGNC VGNC:61021
Rattus norvegicus CNN1 RGD RGD:621883
Macaca mulatta CNN1 VGNC VGNC:71277
Others CNN1 NCBI