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PHC2 - polyhomeotic homolog 2 Gene

Also Known as PH2; EDR2; HPH2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1912

About PHC2

Cytogenetic location: 1p35.1 Genomic coordinates (GRCh38): 1:33,323,626-33,431,095 (from NCBI)

This gene has 13 transcripts (splice variants), 149 orthologues and 18 paralogues. Ubiquitous expression in testis (RPKM 13.8), endometrium (RPKM 13.8) and 25 other tissues.

Summary

In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein 'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PHC2 Products (10)

mRNA	Protein	Name
NM_001330488.2	NP_001317417.1	polyhomeotic-like protein 2 isoform c
NM_001385109.1	NP_001372038.1	polyhomeotic-like protein 2 isoform e
NM_001385112.1	NP_001372041.1	polyhomeotic-like protein 2 isoform d
NM_001385119.1	NP_001372048.1	polyhomeotic-like protein 2 isoform e
NM_001385120.1	NP_001372049.1	polyhomeotic-like protein 2 isoform e
NM_001385121.1	NP_001372050.1	polyhomeotic-like protein 2 isoform f
NM_001385122.1	NP_001372051.1	polyhomeotic-like protein 2 isoform c
NM_001385123.1	NP_001372052.1	polyhomeotic-like protein 2 isoform g
NM_004427.4	NP_004418.2	polyhomeotic-like protein 2 isoform b
NM_198040.3	NP_932157.1	polyhomeotic-like protein 2 isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10976766	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of PRC1 complex	IDA IDA: Inferred from direct assay	12167701	GOA
part of PcG protein complex	IDA IDA: Inferred from direct assay	21282530	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21282530	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PHC2 Protein Structure

SAM_1

0
200
400
600
800
858 a.a.

Protein Preferred Names	Protein Names
polyhomeotic-like protein 2	early development regulator 2 (homolog of polyhomeotic 2)

PHC2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PHC2	Q8IXK0	ZGPAT	Homo sapiens	Q8N5A5-2	Validated Y2H	25416956
Intra	PHC2	Q8IXK0	ZGPAT	Homo sapiens	Q8N5A5-2	Y2H Prey Pooling	25416956
Intra	PHC2	Q8IXK0	ZGPAT	Homo sapiens	Q8N5A5-2	Y2H Array	25416956
Intra	PHC2	Q8IXK0	SYT16	Homo sapiens	Q17RD7	Y2H Prey Pooling	25416956
Intra	PHC2	Q8IXK0	SYT16	Homo sapiens	Q17RD7	Validated Y2H	25416956
Intra	PHC2	Q8IXK0	FAM74A1	Homo sapiens	Q5RGS3	Y2H Prey Pooling	25416956
Intra	PHC2	Q8IXK0	FAM74A1	Homo sapiens	Q5RGS3	Y2H Array	25416956
Intra	PHC2	Q8IXK0	MAB21L3	Homo sapiens	Q8N8X9	Y2H Prey Pooling	25416956
Intra	PHC2	Q8IXK0	MAB21L3	Homo sapiens	Q8N8X9	Y2H Array	25416956
Intra	PHC2	Q8IXK0	PPP1R16B	Homo sapiens	Q96T49	Validated Y2H	25416956
Intra	PHC2	Q8IXK0	PPP1R16B	Homo sapiens	Q96T49	Y2H Array	31515488
Intra	PHC2	Q8IXK0	PRKAA1	Homo sapiens	Q13131	Y2H Prey Pooling	25416956
Intra	PHC2	Q8IXK0	PRKAA1	Homo sapiens	Q13131	Y2H Array	25416956
Intra	PHC2	Q8IXK0	PRKAA1	Homo sapiens	Q13131	Validated Y2H	25416956
Intra	PHC2	Q8IXK0	PRPF31	Homo sapiens	Q8WWY3	Y2H Array	25416956
Intra	PHC2	Q8IXK0	PRPF31	Homo sapiens	Q8WWY3	Y2H Prey Pooling	25416956
Intra	PHC2	Q8IXK0	PRPF31	Homo sapiens	Q8WWY3	Validated Y2H	25416956
Intra	PHC2	Q8IXK0	PCGF2	Homo sapiens	P35227	TAP	27705803
Intra	PHC2	Q8IXK0	PCGF2	Homo sapiens	P35227	Validated Y2H	25416956
Intra	PHC2	Q8IXK0	PCGF2	Homo sapiens	P35227	Y2H Array	25416956
Intra	PHC2	Q8IXK0	SSX2IP	Homo sapiens	Q9Y2D8	Y2H Prey Pooling	25416956
Intra	PHC2	Q8IXK0	SSX2IP	Homo sapiens	Q9Y2D8	Validated Y2H	25416956
Intra	PHC2	Q8IXK0	SSX2IP	Homo sapiens	Q9Y2D8	Y2H Array	25416956
Intra	PHC2	Q8IXK0	PCGF3	Homo sapiens	Q3KNV8	Validated Y2H	25416956
Intra	PHC2	Q8IXK0	PCGF3	Homo sapiens	Q3KNV8	Y2H Array	25416956
Intra	PHC2	Q8IXK0	BMI1	Homo sapiens	P35226	Y2H Prey Pooling	25416956
Intra	PHC2	Q8IXK0	BMI1	Homo sapiens	P35226	TAP	27705803
Intra	PHC2	Q8IXK0	ZMAT2	Homo sapiens	Q96NC0	Validated Y2H	25416956
Intra	PHC2	Q8IXK0	L3MBTL3	Homo sapiens	Q96JM7	Y2H Prey Pooling	25416956
Intra	PHC2	Q8IXK0	PCGF5	Homo sapiens	Q86SE9	Y2H Prey Pooling	25416956
Intra	PHC2	Q8IXK0	PCGF5	Homo sapiens	Q86SE9	Y2H Array	25416956
Intra	PHC2	Q8IXK0	SP1	Homo sapiens	P08047	Pull Down	10976766
Intra	PHC2	Q8IXK0	SP1	Homo sapiens	P08047	Y2H	10976766
Intra	PHC2	Q8IXK0	ZGPAT	Homo sapiens	Q8N5A5	Y2H Prey Pooling	25416956
Intra	PHC2	Q8IXK0	SMAD3	Homo sapiens	P84022	Validated Y2H	25416956
Intra	PHC2	Q8IXK0	SMAD3	Homo sapiens	P84022	Y2H Array	25416956
Intra	PHC2	Q8IXK0	MCRS1	Homo sapiens	Q96EZ8	Y2H Pooling	16189514
Intra	PHC2	Q8IXK0	BYSL	Homo sapiens	Q13895	Validated Y2H	25416956
Intra	PHC2	Q8IXK0	BYSL	Homo sapiens	Q13895	Y2H Prey Pooling	25416956
Intra	PHC2	Q8IXK0	BYSL	Homo sapiens	Q13895	Y2H Array	25416956
Intra	PHC2	Q8IXK0	POLR2L	Homo sapiens	P62875	Y2H Prey Pooling	25416956
Intra	PHC2	Q8IXK0	POLR2L	Homo sapiens	P62875	Validated Y2H	25416956
Intra	PHC2	Q8IXK0	POLR2L	Homo sapiens	P62875	Y2H Array	25416956
Intra	PHC2	Q8IXK0	RBM39	Homo sapiens	Q14498	Validated Y2H	25416956
Intra	PHC2	Q8IXK0	RBM39	Homo sapiens	Q14498	Y2H Prey Pooling	25416956
Intra	PHC2	Q8IXK0	KAT5	Homo sapiens	Q92993	Validated Y2H	25416956
Intra	PHC2	Q8IXK0	KAT5	Homo sapiens	Q92993	Y2H Array	25416956
Intra	PHC2	Q8IXK0	MORF4L2	Homo sapiens	Q15014	Y2H Array	25416956
Intra	PHC2	Q8IXK0	KBTBD7	Homo sapiens	Q8WVZ9	Validated Y2H	25416956
Intra	PHC2	Q8IXK0	KBTBD7	Homo sapiens	Q8WVZ9	Y2H Array	25416956
Intra	PHC2	Q8IXK0	PLK1	Homo sapiens	P53350	Anti Tag CoIP	21988832
Intra	PHC2	Q8IXK0	AP1M1	Homo sapiens	Q9BXS5	Y2H Prey Pooling	25416956
Intra	PHC2	Q8IXK0	AP1M1	Homo sapiens	Q9BXS5	Validated Y2H	25416956
Intra	PHC2	Q8IXK0	MAGEB6	Homo sapiens	Q8N7X4	Validated Y2H	25416956
Intra	PHC2	Q8IXK0	RBM39	Homo sapiens	Q14498-3	Validated Y2H	25416956
Intra	PHC2	Q8IXK0	RBM39	Homo sapiens	Q14498-3	Y2H Array	25416956
Intra	PHC2	Q8IXK0	CBX8	Homo sapiens	Q9HC52	Y2H Prey Pooling	25416956
Intra	PHC2	Q8IXK0	CBX8	Homo sapiens	Q9HC52	TAP	27705803
Intra	PHC2	Q8IXK0	DRG1	Homo sapiens	Q9Y295	Validated Y2H	25416956
Intra	PHC2	Q8IXK0	DRG1	Homo sapiens	Q9Y295	Y2H	21516116
Intra	PHC2	Q8IXK0	DRG1	Homo sapiens	Q9Y295	Y2H Prey Pooling	25416956
Intra	PHC2	Q8IXK0	FAM161A	Homo sapiens	Q3B820	Validated Y2H	25416956
Intra	PHC2	Q8IXK0	FAM161A	Homo sapiens	Q3B820	Y2H Array	25416956
Intra	PHC2	Q8IXK0	RWDD2B	Homo sapiens	P57060	Y2H Array	25416956
Intra	PHC2	Q8IXK0	RWDD2B	Homo sapiens	P57060	Y2H Prey Pooling	25416956
Intra	PHC2	Q8IXK0	TRIM41	Homo sapiens	Q8WV44	Y2H Prey Pooling	25416956
Intra	PHC2	Q8IXK0	SDCBP	Homo sapiens	O00560	Validated Y2H	25416956
Intra	PHC2	Q8IXK0	SDCBP	Homo sapiens	O00560	Y2H Array	25416956
Intra	PHC2	Q8IXK0	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	25416956
Intra	PHC2	Q8IXK0	LMO2	Homo sapiens	P25791	Y2H Array	25416956
Intra	PHC2	Q8IXK0	LMO2	Homo sapiens	P25791	Y2H Prey Pooling	25416956
Intra	PHC2	Q8IXK0	ZNF417	Homo sapiens	Q8TAU3	Y2H Prey Pooling	25416956
Intra	PHC2	Q8IXK0	ZNF417	Homo sapiens	Q8TAU3	Y2H Array	25416956
Intra	PHC2	Q8IXK0	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	25416956
Intra	PHC2	Q8IXK0	ZBTB24	Homo sapiens	O43167	Y2H Array	25416956
Intra	PHC2	Q8IXK0	ZBTB24	Homo sapiens	O43167	Validated Y2H	25416956
Intra	PHC2	Q8IXK0	FAM124A	Homo sapiens	Q86V42	Y2H Prey Pooling	25416956
Intra	PHC2	Q8IXK0	SIAH1	Homo sapiens	Q8IUQ4	Validated Y2H	25416956
Intra	PHC2	Q8IXK0	SIAH1	Homo sapiens	Q8IUQ4	Y2H Prey Pooling	25416956
Intra	PHC2	Q8IXK0	SIAH1	Homo sapiens	Q8IUQ4	Y2H	21516116
Intra	PHC2	Q8IXK0	SIAH1	Homo sapiens	Q8IUQ4	Y2H Array	25416956
Intra	PHC2	Q8IXK0	SIAH1	Homo sapiens	Q8IUQ4	Y2H	21988832
Intra	PHC2	Q8IXK0	SFMBT1	Homo sapiens	Q9UHJ3	Validated Y2H	25416956
Intra	PHC2	Q8IXK0	SFMBT1	Homo sapiens	Q9UHJ3	Y2H Prey Pooling	25416956
Intra	PHC2	Q8IXK0	FAM13C	Homo sapiens	Q8NE31	Y2H Array	25416956
Intra	PHC2	Q8IXK0	CARD9	Homo sapiens	Q9H257	Y2H Prey Pooling	25416956
Intra	PHC2	Q8IXK0	CARD9	Homo sapiens	Q9H257	Y2H Array	25416956
Intra	PHC2	Q8IXK0	AEN	Homo sapiens	Q8WTP8	Validated Y2H	25416956
Intra	PHC2	Q8IXK0	AEN	Homo sapiens	Q8WTP8	Y2H Array	25416956
Intra	PHC2	Q8IXK0	AEN	Homo sapiens	Q8WTP8	Y2H Prey Pooling	25416956
Intra	PHC2	Q8IXK0	LMO1	Homo sapiens	P25800	Y2H Array	25416956
Intra	PHC2	Q8IXK0	LMO1	Homo sapiens	P25800	Y2H Prey Pooling	25416956
Intra	PHC2	Q8IXK0	AIRIM	Homo sapiens	Q9NX04	Y2H Prey Pooling	25416956
Intra	PHC2	Q8IXK0	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	25416956
Intra	PHC2	Q8IXK0	AIRIM	Homo sapiens	Q9NX04	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Conventional Angiosarcoma
Akinetopsia
Form Agnosia
Pontocerebellar Hypoplasia, Type 12	PCH12 Pontocerebellar Hypoplasia Type 12 Coasy-Related Pontocerebellar Hypoplasia Pontocerebellar Hypoplasia 12 Doid:0112327 Hypoplasia, Pontocerebellar, Type 12

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10410	PHC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PHC2	VGNC	VGNC:64134
Mus musculus	PHC2	MGD	MGI:1860454
Canis familiaris	PHC2	VGNC	VGNC:44478
Rattus norvegicus	PHC2	RGD	RGD:1307912
Macaca mulatta	PHC2	VGNC	VGNC:75903
Bos taurus	PHC2	VGNC	VGNC:32811
Others	PHC2	NCBI