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FLRT1 - fibronectin leucine rich transmembrane protein 1 Gene

Also Known as SPG68

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23769

About FLRT1

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,035,931-64,119,171 (from NCBI)

This gene has 2 transcripts (splice variants), 253 orthologues, 22 paralogues and is associated with 1 phenotype. Broad expression in brain (RPKM 4.3), adrenal (RPKM 3.2) and 14 other tissues.

Summary

This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two Other family members, FLRT2 and FLRT3. This gene is expressed in kidney and brain. [provided by RefSeq, Jul 2008]

FLRT1 Products (2)

mRNA	Protein	Name
NM_001384466.1	NP_001371395.1	leucine-rich repeat transmembrane protein FLRT1
NM_013280.5	NP_037412.2	leucine-rich repeat transmembrane protein FLRT1

FLRT1 Protein Structure

LRRNT

LRR_8

0
200
400
600
674 a.a.

Protein Preferred Names	Protein Names
leucine-rich repeat transmembrane protein FLRT1	fibronectin-like domain-containing leucine-rich transmembrane protein 1

Recombinant FLRT1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70925	FLRT1 Protein, Human (HEK293, His)	Q9NZU1-1 (I21-P524)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Spastic Paraplegia, Optic Atrophy, And Neuropathy	Spoan Syndrome SPOAN Spastic Paraplegia, Optic Atropy, And Neuropathy Spastic Paraplegia, Optic Atropy, And Neuropathy Syndrome Spastic Paraplegia-Optic Atrophy-Neuropathy Syndrome
Spastic Paraplegia 8, Autosomal Dominant	SPG8 Hereditary Spastic Paraplegia 8 Autosomal Dominant Spastic Paraplegia Type 8 Autosomal Dominant Spastic Paraplegia 8 Paraplegia, Spastic, Autosomal Dominant, Type 8
Spastic Paraplegia 6, Autosomal Dominant	SPG6 Fsp3 Hereditary Spastic Paraplegia 6 Autosomal Dominant Spastic Paraplegia Type 6 Spastic Paraplegia 6 Familial Spastic Paraplegia Autosomal Dominant 3 Familial Spastic Paraplegia, Autosomal Dominant, 3 Autosomal Dominant Familial Spastic Paraplegia Type 3 Autosomal Dominant Spastic Paraplegia 6 Spastic Paraplegia-6 Paraplegia, Spastic, Type 6
Spastic Ataxia 3
Motor Neuron Disease	Anterior Horn Cell Disease Motor Neuron Diseases Mnd - [Motor Neurone Disease] Lou Gehrig Disease Creeping Palsy Creeping Paralysis Bulbar Motor Neuron Disease Bulbar Syndrome Anterior Horn Cell Disorder Hereditary Motor Neuron Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04984	FLRT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19194	Flrt1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25682	Flrt1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FLRT1	VGNC	VGNC:40904
Macaca mulatta	FLRT1	VGNC	VGNC:72675
Felis catus	FLRT1	VGNC	VGNC:62296
Mus musculus	FLRT1	MGD	MGI:3026647
Rattus norvegicus	FLRT1	RGD	RGD:1565152
Bos taurus	FLRT1	VGNC	VGNC:29038
Others	FLRT1	NCBI