FOXK2 - forkhead box K2 Gene

Also Known as ILF; ILF1; ILF-1; nGTBP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3607

About FOXK2

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:82,519,732-82,604,602 (from NCBI)

This gene has 12 transcripts (splice variants), 273 orthologues and 42 paralogues. Ubiquitous expression in testis (RPKM 11.2), brain (RPKM 8.3) and 25 other tissues.

Summary

The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements. [provided by RefSeq, Jul 2008]

FOXK2 Products (1)

mRNA Protein Name
NM_004514.4 NP_004505.2 forkhead box protein K2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
9065434 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
9065434 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
16624804 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21903422 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
1339390 GOA
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
22083952 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
20810654 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
22083952 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9065434 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
20810654 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXK2 Protein Structure

FHA

FHA: FHA domain (54 - 130)

Forkhead

Forkhead: Forkhead domain (258 - 352)

  • 0
  • 200
  • 400
  • 600
  • 660 a.a.
Protein Preferred Names Protein Names

forkhead box protein K2

  • FOXK1

FOXK2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FOXK2 Q01167 IRF2 Homo sapiens P14316
Anti Tag CoIP
21903422
Intra
FOXK2 Q01167 IRF2 Homo sapiens P14316
TAP
25609649
Intra
FOXK2 Q01167 MAX Homo sapiens P61244
TAP
25609649
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Bainbridge-Ropers Syndrome

  • BRPS

  • Severe Feeding Difficulties-Failure To Thrive-Microcephaly Due To Asxl3 Deficiency Syndrome

  • Asxl3-Related Disorder
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05060 FOXK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus FOXK2 MGD MGI:1916087
Bos taurus FOXK2 VGNC VGNC:55831
Felis catus FOXK2 VGNC VGNC:67789
Macaca mulatta FOXK2 VGNC VGNC:72711
Canis familiaris FOXK2 VGNC VGNC:84864
Rattus norvegicus FOXK2 RGD RGD:1305408
Others FOXK2 NCBI