PDIA4 - protein disulfide isomerase family A member 4 Gene

Also Known as ERP70; ERP72; ERp-72

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9601

About PDIA4

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:149,003,051-149,028,505 (from NCBI)

This gene has 4 transcripts (splice variants), 212 orthologues and 13 paralogues. Broad expression in thyroid (RPKM 166.5), liver (RPKM 67.6) and 24 other tissues.

Summary

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. This protein, when bound to Cyclophilin B, enhances the rate of immunoglobulin G intermolecular disulfide bonding and antibody assembly. [provided by RefSeq, Dec 2016]

PDIA4 Products (3)

mRNA	Protein	Name
NM_001371244.1	NP_001358173.1	protein disulfide-isomerase A4 isoform 1 precursor
NM_001371245.1	NP_001358174.1	protein disulfide-isomerase A4 isoform 3 precursor
NM_004911.5	NP_004902.1	protein disulfide-isomerase A4 isofrom 2 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16287128	GOA
enables protein-disulfide reductase activity	IDA IDA: Inferred from direct assay	16677074	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	19995400	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	19995400	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDIA4 Protein Structure

Thioredoxin

Thioredoxin_6

Thioredoxin

0
100
200
300
400
500
600
645 a.a.

Protein Preferred Names	Protein Names
protein disulfide-isomerase A4	ER protein 70

PDIA4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PDIA4	P13667	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	32296183
Intra	PDIA4	P13667	KRTAP12-1	Homo sapiens	P59990	Validated Y2H	32296183
Intra	PDIA4	P13667	KRTAP4-11	Homo sapiens	Q9BYQ6	Validated Y2H	32296183
Intra	PDIA4	P13667	LCN2	Homo sapiens	P80188	Y2H Array	32296183
Intra	PDIA4	P13667	LCN2	Homo sapiens	P80188	Y2H Prey Pooling	32296183
Intra	PDIA4	P13667	LCN2	Homo sapiens	P80188	Validated Y2H	32296183
Intra	PDIA4	P13667	PPIB	Homo sapiens	P23284	Crosslink	30021884
Cross	PDIA4	P13667	q76353_9hiv1	Human immunodeficiency virus	Q76353	Pull Down	22190034
Intra	PDIA4	P13667	EMC7	Homo sapiens	Q9NPA0	Anti Tag CoIP	33961781
Intra	PDIA4	P13667	EMC7	Homo sapiens	Q9NPA0	Anti Tag CoIP	28514442
Intra	PDIA4	P13667	P23284-PRO_0000025479	Homo sapiens	P23284-PRO_0000025479	Pull Down	22665516

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PDIA4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71113	PDIA4 Protein, Human (HEK293, His)	P13667 (V21-L645)	≥ 95%, as determined by reducing SDS-PAGE.

PDIA4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80123	ERp72 Antibody (YA769)	WB, IHC-P, IHC-F, IF-Tissue	Human

Related Diseases

Diseases	Alias
Multiple Epiphyseal Dysplasia	Med Polyepiphyseal Dysplasia Edm Epiphyseal Dysplasia, Multiple, 1 Epiphyseal Dysplasia, Multiple, 2 Epiphyseal Dysplasia, Multiple, 3 Epiphyseal Dysplasia, Multiple, 4 Epiphyseal Dysplasia, Multiple, 5 Epiphyseal Dysplasia, Multiple Edm1 Edm2 Edm3 Edm4 Edm5 Epiphyseal Dysplasia, Fairbank Type Epiphyseal Dysplasia, Ribbing Type Multiple Epiphyseal Dysplasia, Autosomal Dominant Multiple Epiphyseal Dysplasia, Autosomal Recessive Rmed Dysplasia, Epiphyseal, Multiple Osteochondrodysplasias
Congenital Hypothyroidism	Cretinism Neonatal Hypothyroidism Ch Cht Congenital Myxedema Myxedema, Congenital Endemic Cretinism Congenital Iodine-Deficiency Syndrome Fetal Iodine Deficiency Syndrome Congenital Iodine-Deficiency Hypothyroidism Nos
Ovarian Dysgenesis 2	Premature Ovarian Failure 4 ODG2 Ovarian Dysgenesis, Hypergonadotropic, X-Linked Ovarian Failure, Hypergonadotropic, Due To Ovarian Dysgenesis Ovarian Failure Hypergonadotropic Due To Ovarian Dysgenesis X-Linked Hypergonadotropic Ovarian Dysgenesis POF4 Dysgenesis, Ovarian, Type 2
Epiphyseal Dysplasia, Multiple, 5	EDM5 Multiple Epiphyseal Dysplasia 5 Bhmed Multiple Epiphyseal Dysplasia Type 5 Multiple Epiphyseal Dysplasia, Matn3-Related Microepiphyseal Dysplasia, Bilateral Hereditary Bilateral Hereditary Microepiphyseal Dysplasia Multiple Epiphyseal Dysplasia Matn3-Related Epiphyseal Dysplasia Multiple 5 Multiple Epiphyseal Dysplasia, Matn3 Related Bilateral Hereditary Micro-Epiphyseal Dysplasia Med5 Polyepiphyseal Dysplasia Type 5 Dysplasia, Epiphyseal, Multiple, Type 5

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122895	E64FC26		98.48%	Unkown
HY-122895A	(E/Z)-E64FC26		99.80%	Unkown
HY-RS10269	PDIA4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17554	Pdia4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24012	Pdia4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PDIA4	VGNC	VGNC:64084
Mus musculus	PDIA4	MGD	MGI:104864
Macaca mulatta	PDIA4	VGNC	VGNC:84750
Canis familiaris	PDIA4	VGNC	VGNC:44377
Bos taurus	PDIA4	VGNC	VGNC:32698
Rattus norvegicus	PDIA4	RGD	RGD:619835
Others	PDIA4	NCBI