LP-661438
LP-661438 (Compound 10) is an orally active DCK inhibitor (IC50 = 1.7 nM). LP-661438 inhibits deoxycytidine kinase in T cells and in vivo.
For research use only. We do not sell to patients.
- CAS No.: 1034174-88-3
- Formula: C23H20FN5O2S
- Molecular Weight:449.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| T-cell | EC50 |
17 nM
Compound: 10
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Inhibition of deoxycytidine kinase in anti CD3 and anti CD28 -stimulated human T cells assessed as reduction in [3H]deoxycitidine incorporation
Inhibition of deoxycytidine kinase in anti CD3 and anti CD28 -stimulated human T cells assessed as reduction in [3H]deoxycitidine incorporation
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[PMID: 19836232] |
| T-cell | EC50 |
90 nM
Compound: 10
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Inhibition of deoxycytidine kinase in anti CD3 and anti CD28 -stimulated mouse T cells assessed as reduction in [3H]deoxycitidine incorporation
Inhibition of deoxycytidine kinase in anti CD3 and anti CD28 -stimulated mouse T cells assessed as reduction in [3H]deoxycitidine incorporation
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[PMID: 19836232] |
Chemical Information
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CAS No. 1034174-88-3
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Molecular Weight 449.50
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Formula C23H20FN5O2S
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SMILES
O=C(N[C@H]1CC[C@H](N2C(N=C(N)C(F)=C2)=O)C1)C3=NC=CC(C4=CC5=CC=CC=C5S4)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LP-661438 Related Classifications
HY-14509 Related Classifications
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