PLK3
PLK3, known historically as PRK or CNK, is the stress- and cytokine-inducible member of the Polo-like kinase family. Unlike PLK1, PLK3 peaks in expression during the early cell cycle and G2, and it operates in checkpoint signaling rather than routine mitotic progression. DNA damage activates PLK3, which phosphorylates Chk2 and p53 and contributes to cell-cycle arrest and apoptosis; it also mediates Golgi fragmentation during stress. PLK3 functions as a tumor suppressor in several malignancies and is frequently silenced epigenetically. Its roles in osteoclast differentiation and adaptation to hypoxia broaden its biological remit. Recombinant PLK3 serves checkpoint and signaling studies.
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PLK3 Recombinant Proteins (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
