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Cat. No.: HY-19942

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TD-5471

TD-5471 is a potent and selective full agonist of the human β₂-adrenoceptor.

For research use only. We do not sell to patients.

CAS No.: 530084-87-8
Formula: C₃₂H₃₁N₃O₄
Molecular Weight:521.61

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

TD-5471 Chemical Structure

CAS No.: 530084-87-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

TD-5471 is a potent and selective full agonist of the human β₂-adrenoceptor^[1].

IC₅₀ & Target

β₂ adrenoceptor^[1]

All Adrenergic Receptor Isoforms :

In Vitro

TD-5471 is potent, with slow onset in an in vitro guinea pig trachea model. TD-5471 has potency with pEC₅₀ of 8.7 in the guinea pig tracheal ring assay.TD-5471 is structurally differentiated from Milveterol (HY-14297) and its long duration of action is consistent with a correlation with hydrophobicity observed in other long-acting β₂-agonist discovery programs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

TD-5471 shows a dose-dependent and long duration of action in an in vivo guinea pig model of bronchoprotection. In a guinea pig model of in vivo bronchoprotection, TD-5471 shows excellent potency (measured 1.5 h after nebulized dosing). TD-5471-mediated bronchoprotection at 72 h is dose-dependent^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 530084-87-8
Molecular Weight 521.61
Formula C₃₂H₃₁N₃O₄
SMILES

O=C1NC2=C(C([C@@H](O)CNCCC3=CC=C(NC4=CC(C5=CC=CC=C5)=C(OC)C=C4)C=C3)=CC=C2O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jacobsen JR, et al. Multivalent design of long-acting β(2)-adrenoceptor agonists incorporating biarylamines. Bioorg Med Chem Lett. 2014 Jun 15;24(12):2625-30. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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