2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. IUN-00433

IUN-00433 (Compound 36) is a selective positive allosteric modulator of α4β1δ-type GABAA receptors, with an EC50 of 0.060 μM. IUN-00433 is applicable to research related to neurological disorders.

For research use only. We do not sell to patients.

IUN-00433

IUN-00433 Chemical Structure

CAS No. : 2188230-70-6

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IUN-00433 Related Antibodies

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Description

IUN-00433 (Compound 36) is a selective positive allosteric modulator of α4β1δ-type GABAA receptors, with an EC50 of 0.060 μM. IUN-00433 is applicable to research related to neurological disorders[1].

IC50 & Target[1]

α4β1δ GABAA

0.060 μM (EC50)

In Vitro

IUN-00433 exerts positive allosteric regulatory activity on α4β1δ, with an EC50 of 0.060 μM, which is 16-fold more potent than DS2[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IUN-00433 Related Antibodies
Molecular Weight

432.72

Formula

C18H11BrClN3OS
CAS No.
SMILES

O=C(C1=CC=C(C=C1)Cl)NC2=C(C3=CC=CS3)N=C4C=CC(Br)=CN42
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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IUN-00433 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IUN-004332188230-70-6IUN00433IUN 00433GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid Receptorα4β1δ GABA?Rsmajor depression disorderGABAepilepsyα4β1γ2 GABA? receptorsalcoholismα4β1δ GABA? receptorsα4β1δ γ-aminobutyric acid type A receptorInhibitorinhibitorinhibit

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