2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. IYPTNGYTR acetate

IYPTNGYTR acetate, a deamidation-sensitive signature peptide, is a deamidation product of Trastuzumab. IYPTNGYTR acetate can be used to monitor in vivo Trastuzumab metabolism.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

IYPTNGYTR acetate Chemical Structure

IYPTNGYTR acetate Chemical Structure

Size Price Stock Quantity
5 mg USD 250 In-stock
10 mg USD 450 In-stock
50 mg   Get quote  
100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of IYPTNGYTR acetate:

IYPTNGYTR acetate Related Antibodies

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Description

IYPTNGYTR acetate, a deamidation-sensitive signature peptide, is a deamidation product of Trastuzumab. IYPTNGYTR acetate can be used to monitor in vivo Trastuzumab metabolism[1].

In Vitro

IYPTNGYTR is deamidated at pH 7.5 and above, with a higher deamidation rate when the pH increases[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IYPTNGYTR acetate Related Antibodies
Molecular Weight

1144.23

Formula

C51H77N13O17
Appearance

Solid

Color

White to off-white

Sequence Shortening

IYPTNGYTR
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (109.24 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8740 mL 4.3698 mL 8.7395 mL
5 mM 0.1748 mL 0.8740 mL 1.7479 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.8740 mL 4.3698 mL 8.7395 mL 21.8488 mL
5 mM 0.1748 mL 0.8740 mL 1.7479 mL 4.3698 mL
10 mM 0.0874 mL 0.4370 mL 0.8740 mL 2.1849 mL
15 mM 0.0583 mL 0.2913 mL 0.5826 mL 1.4566 mL
20 mM 0.0437 mL 0.2185 mL 0.4370 mL 1.0924 mL
25 mM 0.0350 mL 0.1748 mL 0.3496 mL 0.8740 mL
30 mM 0.0291 mL 0.1457 mL 0.2913 mL 0.7283 mL
40 mM 0.0218 mL 0.1092 mL 0.2185 mL 0.5462 mL
50 mM 0.0175 mL 0.0874 mL 0.1748 mL 0.4370 mL
60 mM 0.0146 mL 0.0728 mL 0.1457 mL 0.3641 mL
80 mM 0.0109 mL 0.0546 mL 0.1092 mL 0.2731 mL
100 mM 0.0087 mL 0.0437 mL 0.0874 mL 0.2185 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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IYPTNGYTR acetate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IYPTNGYTRDrug MetabolitedeamidationsignaturepeptideTrastuzumabmetabolismInhibitorinhibitorinhibit

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